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Epigenomic and metabolic responses of hypothalamic POMC neurons to gestational nicotine exposure in adult offspring

BACKGROUND: Epidemiological and animal studies have reported that prenatal nicotine exposure (PNE) leads to obesity and type-2 diabetes in offspring. Central leptin-melanocortin signaling via hypothalamic arcuate proopiomelanocortin (POMC) neurons is crucial for the regulation of energy and glucose...

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Detalles Bibliográficos
Autores principales:	Silva, Jose P., Lambert, Guerline, van Booven, Derek, Wahlestedt, Claes
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015242/ https://www.ncbi.nlm.nih.gov/pubmed/27609221 http://dx.doi.org/10.1186/s13073-016-0348-2

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