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Epigenomic and metabolic responses of hypothalamic POMC neurons to gestational nicotine exposure in adult offspring
BACKGROUND: Epidemiological and animal studies have reported that prenatal nicotine exposure (PNE) leads to obesity and type-2 diabetes in offspring. Central leptin-melanocortin signaling via hypothalamic arcuate proopiomelanocortin (POMC) neurons is crucial for the regulation of energy and glucose...
Autores principales: | Silva, Jose P., Lambert, Guerline, van Booven, Derek, Wahlestedt, Claes |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015242/ https://www.ncbi.nlm.nih.gov/pubmed/27609221 http://dx.doi.org/10.1186/s13073-016-0348-2 |
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