Casitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformation

BACKGROUND: Casitas B-lineage lymphoma (Cbl or c-Cbl) is a RING ubiquitin ligase that negatively regulates protein tyrosine kinase (PTK) signalling. Phosphorylation of a conserved residue (Tyr371) on the linker helix region (LHR) between the substrate-binding and RING domains is required to ubiquiti...

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Detalles Bibliográficos
Autores principales: Buetow, Lori, Tria, Giancarlo, Ahmed, Syed Feroj, Hock, Andreas, Dou, Hao, Sibbet, Gary J., Svergun, Dmitri I., Huang, Danny T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015263/
https://www.ncbi.nlm.nih.gov/pubmed/27609087
http://dx.doi.org/10.1186/s12915-016-0298-6

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