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Cytomegalovirus‐Productive Infection Is Associated With Acute Coronary Syndrome
BACKGROUND: Although an association between human herpesvirus (HHV) infection and atherosclerosis has been suggested, the data supporting such an association are controversial and, in most cases, are based on serological evidence or on the presence of cell‐associated HHV DNA, which do not report abo...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015295/ https://www.ncbi.nlm.nih.gov/pubmed/27543799 http://dx.doi.org/10.1161/JAHA.116.003759 |
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author | Nikitskaya, Elizaveta Lebedeva, Anna Ivanova, Oxana Maryukhnich, Elena Shpektor, Alexander Grivel, Jean‐Charles Margolis, Leonid Vasilieva, Elena |
author_facet | Nikitskaya, Elizaveta Lebedeva, Anna Ivanova, Oxana Maryukhnich, Elena Shpektor, Alexander Grivel, Jean‐Charles Margolis, Leonid Vasilieva, Elena |
author_sort | Nikitskaya, Elizaveta |
collection | PubMed |
description | BACKGROUND: Although an association between human herpesvirus (HHV) infection and atherosclerosis has been suggested, the data supporting such an association are controversial and, in most cases, are based on serological evidence or on the presence of cell‐associated HHV DNA, which do not report about actual viral replication. We quantified the DNA of all 8 types of HHVs in plasma, in which their presence is evidence of viral replication. METHODS AND RESULTS: Using quantitative real‐time polymerase chain reaction, we evaluated the presence of HHV DNA in blood samples obtained at the time of hospitalization from 71 patients with acute coronary syndrome, 26 patients with stable coronary artery disease, and 53 healthy volunteers and in atherosclerotic plaques of 22 patients with peripheral artery disease who underwent endarterectomy. HHV‐5 (cytomegalovirus [CMV]) was the only HHV with a level that was higher in acute coronary syndrome patients than in the control group and that correlated with the level of high‐sensitivity C‐reactive protein. The numbers of effector memory T cells positively correlated with the numbers of CMV genome copies in carotid arteries plaques, whereas the numbers of central memory T cells negatively correlated with CMV copy numbers. CONCLUSIONS: Of all HHV levels, only CMV was higher in patients with stable coronary artery disease and acute coronary syndrome than in the healthy group, and its load correlated with the level of high‐sensitivity C‐reactive protein. The level of CMV in atherosclerotic plaques correlated with the state of immunoactivation of lymphocytes in plaques, suggesting that the reactivation of CMV may contribute to the immune activation associated with the progression of atherosclerosis. |
format | Online Article Text |
id | pubmed-5015295 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-50152952016-09-19 Cytomegalovirus‐Productive Infection Is Associated With Acute Coronary Syndrome Nikitskaya, Elizaveta Lebedeva, Anna Ivanova, Oxana Maryukhnich, Elena Shpektor, Alexander Grivel, Jean‐Charles Margolis, Leonid Vasilieva, Elena J Am Heart Assoc Original Research BACKGROUND: Although an association between human herpesvirus (HHV) infection and atherosclerosis has been suggested, the data supporting such an association are controversial and, in most cases, are based on serological evidence or on the presence of cell‐associated HHV DNA, which do not report about actual viral replication. We quantified the DNA of all 8 types of HHVs in plasma, in which their presence is evidence of viral replication. METHODS AND RESULTS: Using quantitative real‐time polymerase chain reaction, we evaluated the presence of HHV DNA in blood samples obtained at the time of hospitalization from 71 patients with acute coronary syndrome, 26 patients with stable coronary artery disease, and 53 healthy volunteers and in atherosclerotic plaques of 22 patients with peripheral artery disease who underwent endarterectomy. HHV‐5 (cytomegalovirus [CMV]) was the only HHV with a level that was higher in acute coronary syndrome patients than in the control group and that correlated with the level of high‐sensitivity C‐reactive protein. The numbers of effector memory T cells positively correlated with the numbers of CMV genome copies in carotid arteries plaques, whereas the numbers of central memory T cells negatively correlated with CMV copy numbers. CONCLUSIONS: Of all HHV levels, only CMV was higher in patients with stable coronary artery disease and acute coronary syndrome than in the healthy group, and its load correlated with the level of high‐sensitivity C‐reactive protein. The level of CMV in atherosclerotic plaques correlated with the state of immunoactivation of lymphocytes in plaques, suggesting that the reactivation of CMV may contribute to the immune activation associated with the progression of atherosclerosis. John Wiley and Sons Inc. 2016-08-20 /pmc/articles/PMC5015295/ /pubmed/27543799 http://dx.doi.org/10.1161/JAHA.116.003759 Text en © 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Research Nikitskaya, Elizaveta Lebedeva, Anna Ivanova, Oxana Maryukhnich, Elena Shpektor, Alexander Grivel, Jean‐Charles Margolis, Leonid Vasilieva, Elena Cytomegalovirus‐Productive Infection Is Associated With Acute Coronary Syndrome |
title | Cytomegalovirus‐Productive Infection Is Associated With Acute Coronary Syndrome |
title_full | Cytomegalovirus‐Productive Infection Is Associated With Acute Coronary Syndrome |
title_fullStr | Cytomegalovirus‐Productive Infection Is Associated With Acute Coronary Syndrome |
title_full_unstemmed | Cytomegalovirus‐Productive Infection Is Associated With Acute Coronary Syndrome |
title_short | Cytomegalovirus‐Productive Infection Is Associated With Acute Coronary Syndrome |
title_sort | cytomegalovirus‐productive infection is associated with acute coronary syndrome |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015295/ https://www.ncbi.nlm.nih.gov/pubmed/27543799 http://dx.doi.org/10.1161/JAHA.116.003759 |
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