Nanoparticle‐Mediated Delivery of Mitochondrial Division Inhibitor 1 to the Myocardium Protects the Heart From Ischemia‐Reperfusion Injury Through Inhibition of Mitochondria Outer Membrane Permeabilization: A New Therapeutic Modality for Acute Myocardial Infarction

BACKGROUND: Mitochondria‐mediated cell death plays a critical role in myocardial ischemia‐reperfusion (IR) injury. We hypothesized that nanoparticle‐mediated drug delivery of mitochondrial division inhibitor 1 (Mdivi1) protects hearts from IR injury through inhibition of mitochondria outer membrane...

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Detalles Bibliográficos
Autores principales: Ishikita, Ayako, Matoba, Tetsuya, Ikeda, Gentaro, Koga, Jun‐ichiro, Mao, Yajing, Nakano, Kaku, Takeuchi, Osamu, Sadoshima, Junichi, Egashira, Kensuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015412/
https://www.ncbi.nlm.nih.gov/pubmed/27451459
http://dx.doi.org/10.1161/JAHA.116.003872

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