Structural insights into Parkin substrate lysine targeting from minimal Miro substrates

Hereditary Parkinson’s disease is commonly caused by mutations in the protein kinase PINK1 or the E3 ubiquitin ligase Parkin, which function together to eliminate damaged mitochondria. PINK1 phosphorylates both Parkin and ubiquitin to stimulate ubiquitination of dozens of proteins on the surface of...

Descripción completa

Detalles Bibliográficos
Autores principales: Klosowiak, Julian L., Park, Sungjin, Smith, Kyle P., French, Michael E., Focia, Pamela J., Freymann, Douglas M., Rice, Sarah E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015425/
https://www.ncbi.nlm.nih.gov/pubmed/27605430
http://dx.doi.org/10.1038/srep33019

Ejemplares similares

Ejemplares similares