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Descriptive epidemiology of Escherichia coli bacteraemia in England, April 2012 to March 2014

We determined the incidence, risk factors and antimicrobial susceptibility associated with Escherichia coli bacteraemia in England over a 24 month period. Case data were obtained from the national mandatory surveillance database, with susceptibility data linked from LabBase2, a voluntary national mi...

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Autores principales: Bou-Antoun, Sabine, Davies, John, Guy, Rebecca, Johnson, Alan P, Sheridan, Elizabeth A, Hope, Russell J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015457/
https://www.ncbi.nlm.nih.gov/pubmed/27608263
http://dx.doi.org/10.2807/1560-7917.ES.2016.21.35.30329
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author Bou-Antoun, Sabine
Davies, John
Guy, Rebecca
Johnson, Alan P
Sheridan, Elizabeth A
Hope, Russell J
author_facet Bou-Antoun, Sabine
Davies, John
Guy, Rebecca
Johnson, Alan P
Sheridan, Elizabeth A
Hope, Russell J
author_sort Bou-Antoun, Sabine
collection PubMed
description We determined the incidence, risk factors and antimicrobial susceptibility associated with Escherichia coli bacteraemia in England over a 24 month period. Case data were obtained from the national mandatory surveillance database, with susceptibility data linked from LabBase2, a voluntary national microbiology database. Between April 2012 and March 2014, 66,512 E. coli bacteraemia cases were reported. Disease incidence increased by 6% from 60.4 per 100,000 population in 2012–13 to 63.5 per 100,000 population in 2013–14 (p < 0.0001). Rates of E. coli bacteraemia varied with patient age and sex, with 70.5% (46,883/66,512) of cases seen in patients aged ≥ 65 years and 52.4% (33,969/64,846) of cases in females. The most common underlying cause of bacteraemia was infection of the genital/urinary tract (41.1%; 27,328/66,512), of which 98.4% (26,891/27,328) were urinary tract infections (UTIs). The majority of cases (76.1%; 50,617/66,512) had positive blood cultures before or within two days of admission and were classified as community onset cases, however 15.7% (10,468/66,512) occurred in patients who had been hospitalised for over a week. Non-susceptibility to ciprofloxacin, third-generation cephalosporins, piperacillin–tazobactam, gentamicin and carbapenems were 18.4% (8,439/45,829), 10.4% (4,256/40,734), 10.2% (4,694/46,186), 9.7% (4,770/49,114) and 0.2% (91/42,986), respectively. Antibiotic non-susceptibility was higher in hospital-onset cases than for those presenting from the community (e.g. ciprofloxacin non-susceptibility was 22.1% (2,234/10,105) for hospital-onset vs 17.4% (5,920/34,069) for community-onset cases). Interventions to reduce the incidence of E. coli bacteraemia will have to target the community setting and UTIs if substantial reductions are to be realised.
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spelling pubmed-50154572016-09-28 Descriptive epidemiology of Escherichia coli bacteraemia in England, April 2012 to March 2014 Bou-Antoun, Sabine Davies, John Guy, Rebecca Johnson, Alan P Sheridan, Elizabeth A Hope, Russell J Euro Surveill Surveillance and Outbreak Report We determined the incidence, risk factors and antimicrobial susceptibility associated with Escherichia coli bacteraemia in England over a 24 month period. Case data were obtained from the national mandatory surveillance database, with susceptibility data linked from LabBase2, a voluntary national microbiology database. Between April 2012 and March 2014, 66,512 E. coli bacteraemia cases were reported. Disease incidence increased by 6% from 60.4 per 100,000 population in 2012–13 to 63.5 per 100,000 population in 2013–14 (p < 0.0001). Rates of E. coli bacteraemia varied with patient age and sex, with 70.5% (46,883/66,512) of cases seen in patients aged ≥ 65 years and 52.4% (33,969/64,846) of cases in females. The most common underlying cause of bacteraemia was infection of the genital/urinary tract (41.1%; 27,328/66,512), of which 98.4% (26,891/27,328) were urinary tract infections (UTIs). The majority of cases (76.1%; 50,617/66,512) had positive blood cultures before or within two days of admission and were classified as community onset cases, however 15.7% (10,468/66,512) occurred in patients who had been hospitalised for over a week. Non-susceptibility to ciprofloxacin, third-generation cephalosporins, piperacillin–tazobactam, gentamicin and carbapenems were 18.4% (8,439/45,829), 10.4% (4,256/40,734), 10.2% (4,694/46,186), 9.7% (4,770/49,114) and 0.2% (91/42,986), respectively. Antibiotic non-susceptibility was higher in hospital-onset cases than for those presenting from the community (e.g. ciprofloxacin non-susceptibility was 22.1% (2,234/10,105) for hospital-onset vs 17.4% (5,920/34,069) for community-onset cases). Interventions to reduce the incidence of E. coli bacteraemia will have to target the community setting and UTIs if substantial reductions are to be realised. European Centre for Disease Prevention and Control (ECDC) 2016-09-01 /pmc/articles/PMC5015457/ /pubmed/27608263 http://dx.doi.org/10.2807/1560-7917.ES.2016.21.35.30329 Text en This article is copyright of The Authors, 2016. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Surveillance and Outbreak Report
Bou-Antoun, Sabine
Davies, John
Guy, Rebecca
Johnson, Alan P
Sheridan, Elizabeth A
Hope, Russell J
Descriptive epidemiology of Escherichia coli bacteraemia in England, April 2012 to March 2014
title Descriptive epidemiology of Escherichia coli bacteraemia in England, April 2012 to March 2014
title_full Descriptive epidemiology of Escherichia coli bacteraemia in England, April 2012 to March 2014
title_fullStr Descriptive epidemiology of Escherichia coli bacteraemia in England, April 2012 to March 2014
title_full_unstemmed Descriptive epidemiology of Escherichia coli bacteraemia in England, April 2012 to March 2014
title_short Descriptive epidemiology of Escherichia coli bacteraemia in England, April 2012 to March 2014
title_sort descriptive epidemiology of escherichia coli bacteraemia in england, april 2012 to march 2014
topic Surveillance and Outbreak Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015457/
https://www.ncbi.nlm.nih.gov/pubmed/27608263
http://dx.doi.org/10.2807/1560-7917.ES.2016.21.35.30329
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