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Study of Invasive Pneumococcal Infection in Adults with Reference to Penicillin Resistance
BACKGROUND: Invasive pneumococcal infections often prove rapidly fatal, even where good medical treatment is readily available. In developed countries, up to 20% of people who contract pneumococcal meningitis die; however, in developing world, mortality is closer to 50%, even among hospitalized pati...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015495/ https://www.ncbi.nlm.nih.gov/pubmed/28042214 http://dx.doi.org/10.4103/0974-2727.187918 |
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author | Muley, Vrishali Avinash Ghadage, Dnyaneshwari Purushottam Yadav, Gauri Eknath Bhore, Arvind Vamanrao |
author_facet | Muley, Vrishali Avinash Ghadage, Dnyaneshwari Purushottam Yadav, Gauri Eknath Bhore, Arvind Vamanrao |
author_sort | Muley, Vrishali Avinash |
collection | PubMed |
description | BACKGROUND: Invasive pneumococcal infections often prove rapidly fatal, even where good medical treatment is readily available. In developed countries, up to 20% of people who contract pneumococcal meningitis die; however, in developing world, mortality is closer to 50%, even among hospitalized patients. The World Health Organization estimated 600,000–800,000 adult deaths each year from pneumococcal pneumonia, meningitis, and sepsis. AIMS: This study aims to estimate isolation rate of invasive pneumococcal infection in adults, to determine the antimicrobial susceptibility profile of Streptococcus pneumoniae isolates and to study the associated risk factors. MATERIALS AND METHODS: A total of 120 patients with suspected invasive infection such as meningitis, septicemia, and pleural effusion, were included in the study. Various clinical specimens such as pus, cerebrospinal fluid, and other sterile body fluids were processed for isolation and identification of S. pneumoniae. Kirby–Bauer disc diffusion method was performed to determine the antimicrobial susceptibility profile. Minimum inhibitory concentration test was performed to determine the penicillin resistance. RESULTS: Of 120 patients, 40 (33.33%) cases were proven by culture to have an invasive pneumococcal infection. The most common clinical condition observed was meningitis followed by pneumonia with pleural effusion and sepsis. Pneumococcal isolates exhibited 40% resistance to cotrimoxazole and 12.73% to chloramphenicol. Two meningeal isolates exhibited penicillin resistance. Comorbidities observed in 21 (52.5%) cases were mainly Diabetes mellitus, smoking, and alcoholism. CONCLUSIONS: Invasive pneumococcal infection has poor prognosis and penicillin-resistant strains have become increasingly common. This study emphasizes the importance of judicious use of antibiotics, especially to refrain their use in mild self-limiting upper respiratory infections. |
format | Online Article Text |
id | pubmed-5015495 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-50154952017-01-01 Study of Invasive Pneumococcal Infection in Adults with Reference to Penicillin Resistance Muley, Vrishali Avinash Ghadage, Dnyaneshwari Purushottam Yadav, Gauri Eknath Bhore, Arvind Vamanrao J Lab Physicians Original Article BACKGROUND: Invasive pneumococcal infections often prove rapidly fatal, even where good medical treatment is readily available. In developed countries, up to 20% of people who contract pneumococcal meningitis die; however, in developing world, mortality is closer to 50%, even among hospitalized patients. The World Health Organization estimated 600,000–800,000 adult deaths each year from pneumococcal pneumonia, meningitis, and sepsis. AIMS: This study aims to estimate isolation rate of invasive pneumococcal infection in adults, to determine the antimicrobial susceptibility profile of Streptococcus pneumoniae isolates and to study the associated risk factors. MATERIALS AND METHODS: A total of 120 patients with suspected invasive infection such as meningitis, septicemia, and pleural effusion, were included in the study. Various clinical specimens such as pus, cerebrospinal fluid, and other sterile body fluids were processed for isolation and identification of S. pneumoniae. Kirby–Bauer disc diffusion method was performed to determine the antimicrobial susceptibility profile. Minimum inhibitory concentration test was performed to determine the penicillin resistance. RESULTS: Of 120 patients, 40 (33.33%) cases were proven by culture to have an invasive pneumococcal infection. The most common clinical condition observed was meningitis followed by pneumonia with pleural effusion and sepsis. Pneumococcal isolates exhibited 40% resistance to cotrimoxazole and 12.73% to chloramphenicol. Two meningeal isolates exhibited penicillin resistance. Comorbidities observed in 21 (52.5%) cases were mainly Diabetes mellitus, smoking, and alcoholism. CONCLUSIONS: Invasive pneumococcal infection has poor prognosis and penicillin-resistant strains have become increasingly common. This study emphasizes the importance of judicious use of antibiotics, especially to refrain their use in mild self-limiting upper respiratory infections. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5015495/ /pubmed/28042214 http://dx.doi.org/10.4103/0974-2727.187918 Text en Copyright: © Journal of Laboratory Physicians http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Muley, Vrishali Avinash Ghadage, Dnyaneshwari Purushottam Yadav, Gauri Eknath Bhore, Arvind Vamanrao Study of Invasive Pneumococcal Infection in Adults with Reference to Penicillin Resistance |
title | Study of Invasive Pneumococcal Infection in Adults with Reference to Penicillin Resistance |
title_full | Study of Invasive Pneumococcal Infection in Adults with Reference to Penicillin Resistance |
title_fullStr | Study of Invasive Pneumococcal Infection in Adults with Reference to Penicillin Resistance |
title_full_unstemmed | Study of Invasive Pneumococcal Infection in Adults with Reference to Penicillin Resistance |
title_short | Study of Invasive Pneumococcal Infection in Adults with Reference to Penicillin Resistance |
title_sort | study of invasive pneumococcal infection in adults with reference to penicillin resistance |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015495/ https://www.ncbi.nlm.nih.gov/pubmed/28042214 http://dx.doi.org/10.4103/0974-2727.187918 |
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