Ritonavir and bull’s eye maculopathy: case report

Objective: To report on a case of retinal pigment epithelium (RPE) toxicity apparently associated with ritonavir. Methods: We describe a case of gradual-onset blurry vision in both eyes in a 30-year-old HIV-positive male on Highly-Active Antiretroviral Therapy (HAART) including ritonavir Results: Th...

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Detalles Bibliográficos
Autores principales: Pinto, Rita, Vila-Franca, Marta, Oliveira Afonso, Cláudia, Ornelas, Conceição, Santos, Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: German Medical Science GMS Publishing House 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015604/
https://www.ncbi.nlm.nih.gov/pubmed/27625933
http://dx.doi.org/10.3205/oc000011
Descripción
Sumario:Objective: To report on a case of retinal pigment epithelium (RPE) toxicity apparently associated with ritonavir. Methods: We describe a case of gradual-onset blurry vision in both eyes in a 30-year-old HIV-positive male on Highly-Active Antiretroviral Therapy (HAART) including ritonavir Results: The patient presented with a visual acuity of 3/10 in each eye, and fundoscopy revealed paracentral pigment mottling. Computerized perimetry showed a ring-scotoma in both eyes. Fluorescein angiography revealed an anular RPE defect in both eyes, congruent with hyperautofluorescent changes on autofluorescence imaging. Full-field ERG was normal. Conclusions: Since ritonavir has previously been linked with toxicity to the RPE, we consider this report as further evidence of this association.

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