Asymmetrical behaviour of disappearance of reticular pseudodrusen in both eyes during long-term follow-up with spectral domain optical coherence tomography

Objective: To describe asymmetrical disappearance of reticular pseudodrusen (RPD) in patients with age-related macular degeneration (AMD). Methods: SDOCTs and infrared images of four patients with RPD were retrospectively collected and evaluated during long-term follow-up of up to 47 months (range 35–47 months). Results: Unilateral fading of RPD was detected on SDOCTs and infrared images in eyes with and without choroidal neovascularisation (CNV) and intravitreal injections. Presence of RPD in the fellow eyes remained stable in three cases, in one case very few RPD newly developed. Three of the four cases demonstrated unilateral outer retinal atrophy following regression of RPD. Conclusions: This report highlights that RPD may almost completely disappear after occurrence and treatment of CNV in neovascular AMD, but also in dry AMD without any treatment and that this phenomenon may be unilateral.