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Unilateral proptosis and blindness caused by meningioma in a patient treated with cyproterone acetate

Cyproterone has antiandrogenic, antigonadotropic, and progestagenic activity. High-dose preparations are used for treatment of prostate cancer and for treatment of hypersexuality. We describe a patient who was referred to our clinic with slowly progressive unilateral proptosis and blindness of the l...

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Autores principales: Sys, Celine, Kestelyn, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: German Medical Science GMS Publishing House 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015623/
https://www.ncbi.nlm.nih.gov/pubmed/27625949
http://dx.doi.org/10.3205/oc000027
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author Sys, Celine
Kestelyn, Philippe
author_facet Sys, Celine
Kestelyn, Philippe
author_sort Sys, Celine
collection PubMed
description Cyproterone has antiandrogenic, antigonadotropic, and progestagenic activity. High-dose preparations are used for treatment of prostate cancer and for treatment of hypersexuality. We describe a patient who was referred to our clinic with slowly progressive unilateral proptosis and blindness of the left eye. He had been treated with high-dose cyproterone actate (CPA) for 23 years. An obvious proptosis and exodeviation of his left eye was noted on ophthalmic examination. Fundoscopy showed left optic atrophy. The literature suggests a link between long-term high-dose exogenous progesterone agonist exposure and the progression and/or development of meningioma. MRI of the brain was performed and revealed multiple meningiomas. One large meningioma located in the anterior temporal lobe extended into the left orbit and caused the proptosis and blindness. Treatment with CPA was stopped and follow-up imaging 11 months later showed a significant decrease in size of the largest meningiomas.
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spelling pubmed-50156232016-09-13 Unilateral proptosis and blindness caused by meningioma in a patient treated with cyproterone acetate Sys, Celine Kestelyn, Philippe GMS Ophthalmol Cases Article Cyproterone has antiandrogenic, antigonadotropic, and progestagenic activity. High-dose preparations are used for treatment of prostate cancer and for treatment of hypersexuality. We describe a patient who was referred to our clinic with slowly progressive unilateral proptosis and blindness of the left eye. He had been treated with high-dose cyproterone actate (CPA) for 23 years. An obvious proptosis and exodeviation of his left eye was noted on ophthalmic examination. Fundoscopy showed left optic atrophy. The literature suggests a link between long-term high-dose exogenous progesterone agonist exposure and the progression and/or development of meningioma. MRI of the brain was performed and revealed multiple meningiomas. One large meningioma located in the anterior temporal lobe extended into the left orbit and caused the proptosis and blindness. Treatment with CPA was stopped and follow-up imaging 11 months later showed a significant decrease in size of the largest meningiomas. German Medical Science GMS Publishing House 2015-06-17 /pmc/articles/PMC5015623/ /pubmed/27625949 http://dx.doi.org/10.3205/oc000027 Text en Copyright © 2015 Sys et al. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License.
spellingShingle Article
Sys, Celine
Kestelyn, Philippe
Unilateral proptosis and blindness caused by meningioma in a patient treated with cyproterone acetate
title Unilateral proptosis and blindness caused by meningioma in a patient treated with cyproterone acetate
title_full Unilateral proptosis and blindness caused by meningioma in a patient treated with cyproterone acetate
title_fullStr Unilateral proptosis and blindness caused by meningioma in a patient treated with cyproterone acetate
title_full_unstemmed Unilateral proptosis and blindness caused by meningioma in a patient treated with cyproterone acetate
title_short Unilateral proptosis and blindness caused by meningioma in a patient treated with cyproterone acetate
title_sort unilateral proptosis and blindness caused by meningioma in a patient treated with cyproterone acetate
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015623/
https://www.ncbi.nlm.nih.gov/pubmed/27625949
http://dx.doi.org/10.3205/oc000027
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