IDH1 and IDH2 mutations as novel therapeutic targets: current perspectives

Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key metabolic enzymes that convert isocitrate to α-ketoglutarate. IDH1/2 mutations define distinct subsets of cancers, including low-grade gliomas and secondary glioblastomas, chondrosarcomas, intrahepatic cholangiocarcinomas, and hematologic mali...

Descripción completa

Detalles Bibliográficos
Autores principales: Mondesir, Johanna, Willekens, Christophe, Touat, Mehdi, de Botton, Stéphane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015873/
https://www.ncbi.nlm.nih.gov/pubmed/27621679
http://dx.doi.org/10.2147/JBM.S70716

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015873/
https://www.ncbi.nlm.nih.gov/pubmed/27621679
http://dx.doi.org/10.2147/JBM.S70716

Ejemplares similares