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IDH1 and IDH2 mutations as novel therapeutic targets: current perspectives

Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key metabolic enzymes that convert isocitrate to α-ketoglutarate. IDH1/2 mutations define distinct subsets of cancers, including low-grade gliomas and secondary glioblastomas, chondrosarcomas, intrahepatic cholangiocarcinomas, and hematologic mali...

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Detalles Bibliográficos
Autores principales:	Mondesir, Johanna, Willekens, Christophe, Touat, Mehdi, de Botton, Stéphane
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2016
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015873/ https://www.ncbi.nlm.nih.gov/pubmed/27621679 http://dx.doi.org/10.2147/JBM.S70716

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