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The Active Metabolite of Warfarin (3'-Hydroxywarfarin) and Correlation with INR, Warfarin and Drug Weekly Dosage in Patients under Oral Anticoagulant Therapy: A Pharmacogenetics Study

OBJECTIVES: Warfarin oral anticoagulant therapy (OAT) requires regular and frequent drug adjustment monitored by INR. Interindividual variability, drug and diet interferences, and genetics (VKORC1 and CYP2C9) make the maintenance/reaching of stable INR a not so easy task. HPLC assessment of warfarin...

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Detalles Bibliográficos
Autores principales:	Gemmati, Donato, Burini, Francesco, Talarico, Anna, Fabbri, Matteo, Bertocco, Cesare, Vigliano, Marco, Moratelli, Stefano, Cuneo, Antonio, Serino, Maria Luisa, Avato, Francesco Maria, Tisato, Veronica, Gaudio, Rosa Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015920/ https://www.ncbi.nlm.nih.gov/pubmed/27606428 http://dx.doi.org/10.1371/journal.pone.0162084

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