RNA-Binding Protein FXR1 Regulates p21 and TERC RNA to Bypass p53-Mediated Cellular Senescence in OSCC

RNA-binding proteins (RBP) regulate numerous aspects of co- and post-transcriptional gene expression in cancer cells. Here, we demonstrate that RBP, fragile X-related protein 1 (FXR1), plays an essential role in cellular senescence by utilizing mRNA turnover pathway. We report that overexpressed FXR...

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Detalles Bibliográficos
Autores principales: Majumder, Mrinmoyee, House, Reniqua, Palanisamy, Nallasivam, Qie, Shuo, Day, Terrence A., Neskey, David, Diehl, J. Alan, Palanisamy, Viswanathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015924/
https://www.ncbi.nlm.nih.gov/pubmed/27606879
http://dx.doi.org/10.1371/journal.pgen.1006306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015924/
https://www.ncbi.nlm.nih.gov/pubmed/27606879
http://dx.doi.org/10.1371/journal.pgen.1006306

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