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Detailed Analysis of the Binding Mode of Vanilloids to Transient Receptor Potential Vanilloid Type I (TRPV1) by a Mutational and Computational Study

Transient receptor potential vanilloid type 1 (TRPV1) is a non-selective cation channel and a multimodal sensor protein. Since the precise structure of TRPV1 was obtained by electron cryo-microscopy, the binding mode of representative agonists such as capsaicin and resiniferatoxin (RTX) has been ext...

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Detalles Bibliográficos
Autores principales:	Ohbuchi, Katsuya, Mori, Yoshikazu, Ogawa, Kazuo, Warabi, Eiji, Yamamoto, Masahiro, Hirokawa, Takatsugu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015962/ https://www.ncbi.nlm.nih.gov/pubmed/27606946 http://dx.doi.org/10.1371/journal.pone.0162543

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