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Seropositivity of Hepatitis B and C among Syrian Multi-transfused Patients with Hemoglobinopathy
BACKGROUND AND OBJECTIVES: Blood transfusion is a lifesaving therapy for patients with hemoglobinopathies. However, the need of frequent transfusion carries the risk of transmitting hepatitis B and C infections which are intermediately prevalent in Syria. Despite screening blood donations with sensi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Università Cattolica del Sacro Cuore
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016018/ https://www.ncbi.nlm.nih.gov/pubmed/27648209 http://dx.doi.org/10.4084/MJHID.2016.046 |
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author | Yazaji, Widad Habbal, Wafa Monem, Fawza |
author_facet | Yazaji, Widad Habbal, Wafa Monem, Fawza |
author_sort | Yazaji, Widad |
collection | PubMed |
description | BACKGROUND AND OBJECTIVES: Blood transfusion is a lifesaving therapy for patients with hemoglobinopathies. However, the need of frequent transfusion carries the risk of transmitting hepatitis B and C infections which are intermediately prevalent in Syria. Despite screening blood donations with sensitive methods, the risk of transmission is still present when infectious blood is donated within the window period. This study aimed to investigate the incidence of HBV and HCV seropositivity, and its association with multiple transfusions among Syrian hemoglobinopathies patients. MATERIALS AND METHODS: HBsAg, anti-HBc, anti-HBs and anti-HCV were tested for 159 Syrian multi-transfused patients by Enzyme-Linked Immunosorbent Assay (ELISA). RESULTS: Thirty-nine of 159 (24.5%) multi-transfused patients were HBsAg/anti-HBc or anti-HCV positive, 26 (16%) of which never visited the dentist, and they either tested postsurgically negative for HBsAg and anti-HCV or never underwent a surgical procedure. On the contrary of anti-HCV seropositivity, HBsAg/anti-HBc seropositivity was significantly associated with the number of blood transfusions, number of blood units and age (P < 0.001). CONCLUSION: About one-sixth of our patients most likely acquired HBV/HCV infection via blood transfusion. Administering HBV vaccine, ensuring the immune status, and monitoring hepatitis markers might considerably minimize the incidence of viral hepatitis among multi-transfused patients. |
format | Online Article Text |
id | pubmed-5016018 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Università Cattolica del Sacro Cuore |
record_format | MEDLINE/PubMed |
spelling | pubmed-50160182016-09-19 Seropositivity of Hepatitis B and C among Syrian Multi-transfused Patients with Hemoglobinopathy Yazaji, Widad Habbal, Wafa Monem, Fawza Mediterr J Hematol Infect Dis Original Article BACKGROUND AND OBJECTIVES: Blood transfusion is a lifesaving therapy for patients with hemoglobinopathies. However, the need of frequent transfusion carries the risk of transmitting hepatitis B and C infections which are intermediately prevalent in Syria. Despite screening blood donations with sensitive methods, the risk of transmission is still present when infectious blood is donated within the window period. This study aimed to investigate the incidence of HBV and HCV seropositivity, and its association with multiple transfusions among Syrian hemoglobinopathies patients. MATERIALS AND METHODS: HBsAg, anti-HBc, anti-HBs and anti-HCV were tested for 159 Syrian multi-transfused patients by Enzyme-Linked Immunosorbent Assay (ELISA). RESULTS: Thirty-nine of 159 (24.5%) multi-transfused patients were HBsAg/anti-HBc or anti-HCV positive, 26 (16%) of which never visited the dentist, and they either tested postsurgically negative for HBsAg and anti-HCV or never underwent a surgical procedure. On the contrary of anti-HCV seropositivity, HBsAg/anti-HBc seropositivity was significantly associated with the number of blood transfusions, number of blood units and age (P < 0.001). CONCLUSION: About one-sixth of our patients most likely acquired HBV/HCV infection via blood transfusion. Administering HBV vaccine, ensuring the immune status, and monitoring hepatitis markers might considerably minimize the incidence of viral hepatitis among multi-transfused patients. Università Cattolica del Sacro Cuore 2016-09-01 /pmc/articles/PMC5016018/ /pubmed/27648209 http://dx.doi.org/10.4084/MJHID.2016.046 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Yazaji, Widad Habbal, Wafa Monem, Fawza Seropositivity of Hepatitis B and C among Syrian Multi-transfused Patients with Hemoglobinopathy |
title | Seropositivity of Hepatitis B and C among Syrian Multi-transfused Patients with Hemoglobinopathy |
title_full | Seropositivity of Hepatitis B and C among Syrian Multi-transfused Patients with Hemoglobinopathy |
title_fullStr | Seropositivity of Hepatitis B and C among Syrian Multi-transfused Patients with Hemoglobinopathy |
title_full_unstemmed | Seropositivity of Hepatitis B and C among Syrian Multi-transfused Patients with Hemoglobinopathy |
title_short | Seropositivity of Hepatitis B and C among Syrian Multi-transfused Patients with Hemoglobinopathy |
title_sort | seropositivity of hepatitis b and c among syrian multi-transfused patients with hemoglobinopathy |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016018/ https://www.ncbi.nlm.nih.gov/pubmed/27648209 http://dx.doi.org/10.4084/MJHID.2016.046 |
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