Cargando…

β(2)-Adrenergic Receptors Chaperone Trapped Bitter Taste Receptor 14 to the Cell Surface as a Heterodimer and Exert Unidirectional Desensitization of Taste Receptor Function

Bitter taste receptors (TAS2Rs) are G-protein-coupled receptors now recognized to be expressed on extraoral cells, including airway smooth muscle (ASM) where they evoke relaxation. TAS2Rs are difficult to express in heterologous systems, with most receptors being trapped intracellularly. We find, ho...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Donghwa, Pauer, Susan H., Yong, Hwan M., An, Steven S., Liggett, Stephen B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2016
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016158/ https://www.ncbi.nlm.nih.gov/pubmed/27342779 http://dx.doi.org/10.1074/jbc.M116.722736

Ejemplares similares

Characterization of the β-d-Glucopyranoside Binding Site of the Human Bitter Taste Receptor hTAS2R16
por: Sakurai, Takanobu, et al.
Publicado: (2010)

Two Distinct Determinants of Ligand Specificity in T1R1/T1R3 (the Umami Taste Receptor)
por: Toda, Yasuka, et al.
Publicado: (2013)

Leptin Suppresses Mouse Taste Cell Responses to Sweet Compounds
por: Yoshida, Ryusuke, et al.
Publicado: (2015)

Recruitment of a Cytoplasmic Chaperone Relay by the A(2A) Adenosine Receptor
por: Bergmayr, Christian, et al.
Publicado: (2013)

Metformin Inhibits Growth Hormone–Mediated Hepatic PDK4 Gene Expression Through Induction of Orphan Nuclear Receptor Small Heterodimer Partner
por: Kim, Yong Deuk, et al.
Publicado: (2012)

Caveolin-1 Alters the Pattern of Cytoplasmic Ca(2+) Oscillations and Ca(2+)-dependent Gene Expression by Enhancing Leukotriene Receptor Desensitization
por: Yeh, Yi-Chun, et al.
Publicado: (2014)

N-Methyl-d-aspartate Receptors Mediate the Phosphorylation and Desensitization of Muscarinic Receptors in Cerebellar Granule Neurons
por: Butcher, Adrian J., et al.
Publicado: (2009)

P2X Receptor Chimeras Highlight Roles of the Amino Terminus to Partial Agonist Efficacy, the Carboxyl Terminus to Recovery from Desensitization, and Independent Regulation of Channel Transitions
por: Allsopp, Rebecca C., et al.
Publicado: (2013)

Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2)
por: Weston, Cathryn, et al.
Publicado: (2015)

Temporal Profiling of Orexin Receptor-Arrestin-Ubiquitin Complexes Reveals Differences between Receptor Subtypes
por: Dalrymple, Matthew B., et al.
Publicado: (2011)

Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties
por: Watkins, Harriet A., et al.
Publicado: (2016)

Identification of Human P2X1 Receptor-interacting Proteins Reveals a Role of the Cytoskeleton in Receptor Regulation
por: Lalo, Ulyana, et al.
Publicado: (2011)

Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors
por: Weston, Cathryn, et al.
Publicado: (2016)

Concomitant Action of Structural Elements and Receptor Phosphorylation Determines Arrestin-3 Interaction with the Free Fatty Acid Receptor FFA4
por: Butcher, Adrian J., et al.
Publicado: (2014)

Interleukin-1 receptor–associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling
por: De Nardo, Dominic, et al.
Publicado: (2018)

Evidence for Follicle-stimulating Hormone Receptor as a Functional Trimer
por: Jiang, Xuliang, et al.
Publicado: (2014)

Analysis of Human Dopamine D(3) Receptor Quaternary Structure
por: Marsango, Sara, et al.
Publicado: (2015)

Insulin receptor cleavage induced by estrogen impairs insulin signaling
por: Yuasa, Tomoyuki, et al.
Publicado: (2021)

Estrogen Receptor α Mediates Proliferation of Osteoblastic Cells Stimulated by Estrogen and Mechanical Strain, but Their Acute Down-regulation of the Wnt Antagonist Sost Is Mediated by Estrogen Receptor β
por: Galea, Gabriel L., et al.
Publicado: (2013)

Molecular Basis for Jagged-1/Serrate Ligand Recognition by the Notch Receptor
por: Whiteman, Pat, et al.
Publicado: (2013)

Targeting Toll-like Receptor (TLR) Signaling by Toll/Interleukin-1 Receptor (TIR) Domain-containing Adapter Protein/MyD88 Adapter-like (TIRAP/Mal)-derived Decoy Peptides
por: Couture, Leah A., et al.
Publicado: (2012)

Critical Role for an Acidic Amino Acid Region in Platelet Signaling by the HemITAM (Hemi-immunoreceptor Tyrosine-based Activation Motif) Containing Receptor CLEC-2 (C-type Lectin Receptor-2)
por: Hughes, Craig E., et al.
Publicado: (2013)

Direct Recruitment of Insulin Receptor and ERK Signaling Cascade to Insulin-Inducible Gene Loci
por: Nelson, Joel D., et al.
Publicado: (2011)

Spatially Restricted G Protein-coupled Receptor Activity via Divergent Endocytic Compartments
por: Jean-Alphonse, Frederic, et al.
Publicado: (2014)

Central Resistin Overexposure Induces Insulin Resistance Through Toll-Like Receptor 4
por: Benomar, Yacir, et al.
Publicado: (2013)

Differential Distribution, Clustering, and Lateral Diffusion of Subtypes of the Inositol 1,4,5-Trisphosphate Receptor
por: Pantazaka, Evangelia, et al.
Publicado: (2011)

Identification and Profiling of Novel α(1A)-Adrenoceptor-CXC Chemokine Receptor 2 Heteromer
por: Mustafa, Sanam, et al.
Publicado: (2012)

Differential G-protein-coupled Receptor Phosphorylation Provides Evidence for a Signaling Bar Code
por: Butcher, Adrian J., et al.
Publicado: (2011)

Canonical Transient Receptor Potential 6 (TRPC6), a Redox-regulated Cation Channel
por: Graham, Sarabeth, et al.
Publicado: (2010)

An Antibody Biosensor Establishes the Activation of the M(1) Muscarinic Acetylcholine Receptor during Learning and Memory
por: Butcher, Adrian J., et al.
Publicado: (2016)

Dynamic Regulation of Quaternary Organization of the M(1) Muscarinic Receptor by Subtype-selective Antagonist Drugs
por: Pediani, John D., et al.
Publicado: (2016)

Insulin Inhibits Cardiac Contractility by Inducing a G(i)-Biased β(2)-Adrenergic Signaling in Hearts
por: Fu, Qin, et al.
Publicado: (2014)

Bitter Taste Receptor Antagonists Inhibit the Bitter taste of Canola Meal Extract in Chickens
por: Kawabata, Fuminori, et al.
Publicado: (2020)

Bitter Taste Sensitivity and the Expression of Bitter Taste Receptors at Different Growth Stages of Chicks
por: Dey, Bapon, et al.
Publicado: (2018)

Bitter Taste Receptors for Asthma Therapeutics
por: Nayak, Ajay P., et al.
Publicado: (2019)

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-mediated Calcium Signaling and Arrhythmias in the Heart Evoked by β-Adrenergic Stimulation
por: Nebel, Merle, et al.
Publicado: (2013)

Glypican-4 Enhances Insulin Signaling via Interaction With the Insulin Receptor and Serves as a Novel Adipokine
por: Ussar, Siegfried, et al.
Publicado: (2012)

Resistin Knockout Mice Exhibit Impaired Adipocyte Glucose-Dependent Insulinotropic Polypeptide Receptor (GIPR) Expression
por: Kim, Su-Jin, et al.
Publicado: (2013)

The Molecular Basis of Ligand Interaction at Free Fatty Acid Receptor 4 (FFA4/GPR120)
por: Hudson, Brian D., et al.
Publicado: (2014)

Exquisite ligand stereoselectivity of a Drosophila juvenile hormone receptor contrasts with its broad agonist repertoire
por: Bittova, Lenka, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_i5j9ae590s7erm34gnao1kducb