Cargando…

Iterative structure-based improvement of a respiratory syncytial virus fusion glycoprotein vaccine

Structure-based design of vaccines has been a long-sought goal, especially the iterative optimization used so successfully with structure-based design of drugs. We previously developed a 1st-generation vaccine antigen called DS-Cav1, comprising a pre-fusion-stabilized form of the fusion (F) glycopro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Joyce, M. Gordon, Zhang, Baoshan, Ou, Li, Chen, Man, Chuang, Gwo-Yu, Druz, Aliaksandr, Kong, Wing-Pui, Lai, Yen-Ting, Rundlet, Emily J., Tsybovsky, Yaroslav, Yang, Yongping, Georgiev, Ivelin S., Guttman, Miklos, Lees, Christopher R., Pancera, Marie, Sastry, Mallika, Soto, Cinque, Stewart-Jones, Guillaume B.E., Thomas, Paul V., Van Galen, Joseph G., Baxa, Ulrich, Lee, Kelly K., Mascola, John R., Graham, Barney S., Kwong, Peter D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016229/ https://www.ncbi.nlm.nih.gov/pubmed/27478931 http://dx.doi.org/10.1038/nsmb.3267

Ejemplares similares

A Cysteine Zipper Stabilizes a Pre-Fusion F Glycoprotein Vaccine for Respiratory Syncytial Virus
por: Stewart-Jones, Guillaume B. E., et al.
Publicado: (2015)

Structure-Based Design of Head-Only Fusion Glycoprotein Immunogens for Respiratory Syncytial Virus
por: Boyington, Jeffrey C., et al.
Publicado: (2016)

Crystal Structure and Immunogenicity of the DS-Cav1-Stabilized Fusion Glycoprotein From Respiratory Syncytial Virus Subtype B
por: Joyce, M. Gordon, et al.
Publicado: (2019)

Protection of calves by a prefusion-stabilized bovine RSV F vaccine
por: Zhang, Baoshan, et al.
Publicado: (2017)

Structure and immune recognition of trimeric prefusion HIV-1 Env
por: Pancera, Marie, et al.
Publicado: (2014)

Structures of HIV-1-Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design
por: Gorman, Jason, et al.
Publicado: (2015)

Adjuvants and the vaccine response to the DS-Cav1-stabilized fusion glycoprotein of respiratory syncytial virus
por: Sastry, Mallika, et al.
Publicado: (2017)

Crystal structure, conformational fixation, and entry-related interactions of mature ligand-free HIV-1 Env
por: Kwon, Young Do, et al.
Publicado: (2015)

Mammalian production of an isotopically enriched outer domain of the HIV-1 gp120 glycoprotein for NMR spectroscopy
por: Sastry, Mallika, et al.
Publicado: (2011)

Antibodyomics: bioinformatics technologies for understanding B‐cell immunity to HIV‐1
por: Kwong, Peter D., et al.
Publicado: (2017)

NEP: web server for epitope prediction based on antibody neutralization of viral strains with diverse sequences
por: Chuang, Gwo-Yu, et al.
Publicado: (2014)

Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses
por: Kanekiyo, Masaru, et al.
Publicado: (2019)

Transplanting Supersites of HIV-1 Vulnerability
por: Zhou, Tongqing, et al.
Publicado: (2014)

Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-120 interface
por: Huang, Jinghe, et al.
Publicado: (2014)

Newcastle Disease Virus-Like Particles Displaying Prefusion-Stabilized SARS-CoV-2 Spikes Elicit Potent Neutralizing Responses
por: Yang, Yongping, et al.
Publicado: (2021)

Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains
por: Zhou, Tongqing, et al.
Publicado: (2020)

Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry
por: Lai, Yen-Ting, et al.
Publicado: (2019)

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1
por: Xu, Kai, et al.
Publicado: (2018)

Preclinical Development of a Fusion Peptide Conjugate as an HIV Vaccine Immunogen
por: Ou, Li, et al.
Publicado: (2020)

Glucose depletion activates mmu-miR-466h-5p expression through oxidative stress and inhibition of histone deacetylation
por: Druz, Aliaksandr, et al.
Publicado: (2012)

Design of Alphavirus Virus-Like Particles Presenting Circumsporozoite Junctional Epitopes That Elicit Protection against Malaria
por: Francica, Joseph R., et al.
Publicado: (2021)

Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs
por: Xu, Kai, et al.
Publicado: (2021)

Crystal structures of trimeric HIV Env with entry inhibitors BMS-378806 and BMS-626529
por: Pancera, Marie, et al.
Publicado: (2017)

Self-assembling SARS-CoV-2 spike-HBsAg nanoparticles elicit potent and durable neutralizing antibody responses via genetic delivery
por: Liu, Cuiping, et al.
Publicado: (2023)

Enhancing Anti-SARS-CoV-2 Neutralizing Immunity by Genetic Delivery of Enveloped Virus-like Particles Displaying SARS-CoV-2 Spikes
por: Yang, Yongping, et al.
Publicado: (2023)

SARS-CoV-2 S2P spike ages through distinct states with altered immunogenicity
por: Olia, Adam S., et al.
Publicado: (2021)

Characterization of broadly neutralizing antibody responses to HIV-1 in a cohort of long term non-progressors
por: González, Nuria, et al.
Publicado: (2018)

Simultaneous Immunization with Multiple Diverse Immunogens Alters Development of Antigen-Specific Antibody-Mediated Immunity
por: Pilewski, Kelsey A., et al.
Publicado: (2021)

Efficient iterative virtual screening with Apache Spark and conformal prediction
por: Ahmed, Laeeq, et al.
Publicado: (2018)

Structure-Based Design of Nipah Virus Vaccines: A Generalizable Approach to Paramyxovirus Immunogen Development
por: Loomis, Rebecca J., et al.
Publicado: (2020)

Iterative screen optimization maximizes the efficiency of macromolecular crystallization
por: Jones, Harrison G., et al.
Publicado: (2019)

Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerability
por: Shi, Wei, et al.
Publicado: (2022)

Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerability
por: Shi, Wei, et al.
Publicado: (2022)

A critical analysis of computational protein design with sparse residue interaction graphs
por: Jain, Swati, et al.
Publicado: (2017)

A Platform Incorporating Trimeric Antigens into Self-Assembling Nanoparticles Reveals SARS-CoV-2-Spike Nanoparticles to Elicit Substantially Higher Neutralizing Responses than Spike Alone
por: Zhang, Baoshan, et al.
Publicado: (2020)

Structure-based design of a single-chain triple-disulfide-stabilized fusion-glycoprotein trimer that elicits high-titer neutralizing responses against human metapneumovirus
por: Ou, Li, et al.
Publicado: (2023)

Surface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody
por: Kwon, Young D., et al.
Publicado: (2018)

A comprehensive influenza reporter virus panel for high-throughput deep profiling of neutralizing antibodies
por: Creanga, Adrian, et al.
Publicado: (2021)

Elicitation of Neutralizing Antibody Responses to HIV-1 Immunization with Nanoparticle Vaccine Platforms
por: Murji, Amyn A., et al.
Publicado: (2021)

Regression Based Iterative Illumination Compensation Method for Multi-Focal Whole Slide Imaging System †
por: Paulik, Róbert, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_44i4huq9c7ouam95d43bqlufkg