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Cannabidiol, among Other Cannabinoid Drugs, Modulates Prepulse Inhibition of Startle in the SHR Animal Model: Implications for Schizophrenia Pharmacotherapy
Schizophrenia is a severe psychiatric disorder that involves positive, negative and cognitive symptoms. Prepulse inhibition of startle reflex (PPI) is a paradigm that assesses the sensorimotor gating functioning and is impaired in schizophrenia patients as well as in animal models of this disorder....
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016523/ https://www.ncbi.nlm.nih.gov/pubmed/27667973 http://dx.doi.org/10.3389/fphar.2016.00303 |
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author | Peres, Fernanda F. Levin, Raquel Almeida, Valéria Zuardi, Antonio W. Hallak, Jaime E. Crippa, José A. Abilio, Vanessa C. |
author_facet | Peres, Fernanda F. Levin, Raquel Almeida, Valéria Zuardi, Antonio W. Hallak, Jaime E. Crippa, José A. Abilio, Vanessa C. |
author_sort | Peres, Fernanda F. |
collection | PubMed |
description | Schizophrenia is a severe psychiatric disorder that involves positive, negative and cognitive symptoms. Prepulse inhibition of startle reflex (PPI) is a paradigm that assesses the sensorimotor gating functioning and is impaired in schizophrenia patients as well as in animal models of this disorder. Recent data point to the participation of the endocannabinoid system in the pathophysiology and pharmacotherapy of schizophrenia. Here, we focus on the effects of cannabinoid drugs on the PPI deficit of animal models of schizophrenia, with greater focus on the SHR (Spontaneously Hypertensive Rats) strain, and on the future prospects resulting from these findings. |
format | Online Article Text |
id | pubmed-5016523 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-50165232016-09-23 Cannabidiol, among Other Cannabinoid Drugs, Modulates Prepulse Inhibition of Startle in the SHR Animal Model: Implications for Schizophrenia Pharmacotherapy Peres, Fernanda F. Levin, Raquel Almeida, Valéria Zuardi, Antonio W. Hallak, Jaime E. Crippa, José A. Abilio, Vanessa C. Front Pharmacol Pharmacology Schizophrenia is a severe psychiatric disorder that involves positive, negative and cognitive symptoms. Prepulse inhibition of startle reflex (PPI) is a paradigm that assesses the sensorimotor gating functioning and is impaired in schizophrenia patients as well as in animal models of this disorder. Recent data point to the participation of the endocannabinoid system in the pathophysiology and pharmacotherapy of schizophrenia. Here, we focus on the effects of cannabinoid drugs on the PPI deficit of animal models of schizophrenia, with greater focus on the SHR (Spontaneously Hypertensive Rats) strain, and on the future prospects resulting from these findings. Frontiers Media S.A. 2016-09-09 /pmc/articles/PMC5016523/ /pubmed/27667973 http://dx.doi.org/10.3389/fphar.2016.00303 Text en Copyright © 2016 Peres, Levin, Almeida, Zuardi, Hallak, Crippa and Abilio. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Peres, Fernanda F. Levin, Raquel Almeida, Valéria Zuardi, Antonio W. Hallak, Jaime E. Crippa, José A. Abilio, Vanessa C. Cannabidiol, among Other Cannabinoid Drugs, Modulates Prepulse Inhibition of Startle in the SHR Animal Model: Implications for Schizophrenia Pharmacotherapy |
title | Cannabidiol, among Other Cannabinoid Drugs, Modulates Prepulse Inhibition of Startle in the SHR Animal Model: Implications for Schizophrenia Pharmacotherapy |
title_full | Cannabidiol, among Other Cannabinoid Drugs, Modulates Prepulse Inhibition of Startle in the SHR Animal Model: Implications for Schizophrenia Pharmacotherapy |
title_fullStr | Cannabidiol, among Other Cannabinoid Drugs, Modulates Prepulse Inhibition of Startle in the SHR Animal Model: Implications for Schizophrenia Pharmacotherapy |
title_full_unstemmed | Cannabidiol, among Other Cannabinoid Drugs, Modulates Prepulse Inhibition of Startle in the SHR Animal Model: Implications for Schizophrenia Pharmacotherapy |
title_short | Cannabidiol, among Other Cannabinoid Drugs, Modulates Prepulse Inhibition of Startle in the SHR Animal Model: Implications for Schizophrenia Pharmacotherapy |
title_sort | cannabidiol, among other cannabinoid drugs, modulates prepulse inhibition of startle in the shr animal model: implications for schizophrenia pharmacotherapy |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016523/ https://www.ncbi.nlm.nih.gov/pubmed/27667973 http://dx.doi.org/10.3389/fphar.2016.00303 |
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