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The effect of hyperoxia on central blood pressure in healthy subjects

INTRODUCTION: Hyperoxia increases total peripheral resistance by acting locally but also inhibits the activity of carotid body chemoreceptors. We studied the effect of hyperoxia on central pressure in normotensive subjects. MATERIAL AND METHODS: Medical air followed by 100% oxygen was provided to 19...

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Autores principales: Siński, Maciej, Lewandowski, Jacek, Dobosiewicz, Anna, Przybylski, Jacek, Abramczyk, Piotr, Gaciong, Zbigniew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2016
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016570/
https://www.ncbi.nlm.nih.gov/pubmed/27695489
http://dx.doi.org/10.5114/aoms.2015.49038
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author Siński, Maciej
Lewandowski, Jacek
Dobosiewicz, Anna
Przybylski, Jacek
Abramczyk, Piotr
Gaciong, Zbigniew
author_facet Siński, Maciej
Lewandowski, Jacek
Dobosiewicz, Anna
Przybylski, Jacek
Abramczyk, Piotr
Gaciong, Zbigniew
author_sort Siński, Maciej
collection PubMed
description INTRODUCTION: Hyperoxia increases total peripheral resistance by acting locally but also inhibits the activity of carotid body chemoreceptors. We studied the effect of hyperoxia on central pressure in normotensive subjects. MATERIAL AND METHODS: Medical air followed by 100% oxygen was provided to 19 subjects (12/7 female/male, age 28.2 ±1.1 years) for 15 min through a non-rebreather mask. Central blood pressure was then measured using applanation tonometry. RESULTS: After the first 2 min of hyperoxia, heart rate decreased significantly (65 ±2.6 beats/min vs. 61 ±2.1 beats/min, p = 0.0002). Peripheral and central blood pressure remained unchanged, while hemoglobin oxygen saturation and subendocardial viability ratio index increased (97 ±0.4% vs. 99 ±0.2%, p = 0.03; 168 ±8.4% vs. 180 ±8.2%, p = 0.009). After 15 min of 100% oxygen ventilation, heart rate and peripheral and central blood pressures remained unchanged from the first 2 min. The augmentation index, augmentation pressure and ejection duration increased as compared to baseline values and those obtained at 2 min (–5.1 ±2.9% vs. –1.2 ±2.6%, p = 0.005 and –4.6 ±2.7% vs. –1.2 ±2.6%, p = 0.0015; –1.3 ±0.7 mm Hg vs. –0.2 ±1.2 mm Hg, p = 0.003 and –1.1 ±0.7 mm Hg vs. –0.2 ±1.2 mm Hg, p = 0.012; 323 ±3.6 ms vs. 330 ±3.5 ms, p = 0.0002 and 326 ±3.5 ms vs. 330 ±3.5 ms, p = 0.021, respectively). CONCLUSIONS: The present study shows that hyperoxia does not affect central blood pressure in young healthy subjects and may improve myocardial blood supply estimated indirectly from applanation tonometry.
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spelling pubmed-50165702016-10-01 The effect of hyperoxia on central blood pressure in healthy subjects Siński, Maciej Lewandowski, Jacek Dobosiewicz, Anna Przybylski, Jacek Abramczyk, Piotr Gaciong, Zbigniew Arch Med Sci Clinical Research INTRODUCTION: Hyperoxia increases total peripheral resistance by acting locally but also inhibits the activity of carotid body chemoreceptors. We studied the effect of hyperoxia on central pressure in normotensive subjects. MATERIAL AND METHODS: Medical air followed by 100% oxygen was provided to 19 subjects (12/7 female/male, age 28.2 ±1.1 years) for 15 min through a non-rebreather mask. Central blood pressure was then measured using applanation tonometry. RESULTS: After the first 2 min of hyperoxia, heart rate decreased significantly (65 ±2.6 beats/min vs. 61 ±2.1 beats/min, p = 0.0002). Peripheral and central blood pressure remained unchanged, while hemoglobin oxygen saturation and subendocardial viability ratio index increased (97 ±0.4% vs. 99 ±0.2%, p = 0.03; 168 ±8.4% vs. 180 ±8.2%, p = 0.009). After 15 min of 100% oxygen ventilation, heart rate and peripheral and central blood pressures remained unchanged from the first 2 min. The augmentation index, augmentation pressure and ejection duration increased as compared to baseline values and those obtained at 2 min (–5.1 ±2.9% vs. –1.2 ±2.6%, p = 0.005 and –4.6 ±2.7% vs. –1.2 ±2.6%, p = 0.0015; –1.3 ±0.7 mm Hg vs. –0.2 ±1.2 mm Hg, p = 0.003 and –1.1 ±0.7 mm Hg vs. –0.2 ±1.2 mm Hg, p = 0.012; 323 ±3.6 ms vs. 330 ±3.5 ms, p = 0.0002 and 326 ±3.5 ms vs. 330 ±3.5 ms, p = 0.021, respectively). CONCLUSIONS: The present study shows that hyperoxia does not affect central blood pressure in young healthy subjects and may improve myocardial blood supply estimated indirectly from applanation tonometry. Termedia Publishing House 2016-08-24 2016-10-01 /pmc/articles/PMC5016570/ /pubmed/27695489 http://dx.doi.org/10.5114/aoms.2015.49038 Text en Copyright: © 2016 Termedia & Banach http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Clinical Research
Siński, Maciej
Lewandowski, Jacek
Dobosiewicz, Anna
Przybylski, Jacek
Abramczyk, Piotr
Gaciong, Zbigniew
The effect of hyperoxia on central blood pressure in healthy subjects
title The effect of hyperoxia on central blood pressure in healthy subjects
title_full The effect of hyperoxia on central blood pressure in healthy subjects
title_fullStr The effect of hyperoxia on central blood pressure in healthy subjects
title_full_unstemmed The effect of hyperoxia on central blood pressure in healthy subjects
title_short The effect of hyperoxia on central blood pressure in healthy subjects
title_sort effect of hyperoxia on central blood pressure in healthy subjects
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016570/
https://www.ncbi.nlm.nih.gov/pubmed/27695489
http://dx.doi.org/10.5114/aoms.2015.49038
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