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Conformal orbit sparing radiation therapy: a treatment option for advanced skin cancer of the parotid and ear region
INTRODUCTION: New surgical methods have enabled resection of previously in‐operable tumours in the region of the parotid gland and ear. This has translated to deeper target volumes being treated with adjuvant radiotherapy. Due to the limitations of existing conformal techniques, alternative planning...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016620/ https://www.ncbi.nlm.nih.gov/pubmed/27648283 http://dx.doi.org/10.1002/jmrs.161 |
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author | Foley, Heath Hopley, Shane Brown, Elizabeth Bernard, Anne Foote, Matthew |
author_facet | Foley, Heath Hopley, Shane Brown, Elizabeth Bernard, Anne Foote, Matthew |
author_sort | Foley, Heath |
collection | PubMed |
description | INTRODUCTION: New surgical methods have enabled resection of previously in‐operable tumours in the region of the parotid gland and ear. This has translated to deeper target volumes being treated with adjuvant radiotherapy. Due to the limitations of existing conformal techniques, alternative planning approaches are required to cover the target volume with appropriate sparing of adjacent critical structures. Although intensity modulated radiation therapy (IMRT) may be able to achieve these goals compared with the existing conformal method, a new orbital sparing radiation therapy (OSRaT) technique was evaluated as an alternative conformal planning process. The study objective was to evaluate the dosimetry of three planning methods: pre‐existing conformal, IMRT and OSRaT techniques. METHODS: Ten patients were planned retrospectively using the existing three‐dimensional conformal radiotherapy (3DCRT), IMRT and OSRaT techniques. Dosimetry was analysed using the homogeneity index (HI), conformity index (CI), the volume of planning target volumes (PTV) under and over treated by the 95% isodose and dose to critical structures. RESULTS: OSRaT achieved superior 95% coverage of the high‐dose PTV while delivering HI similar to IMRT for intermediate and high‐dose PTVs. The CI for the high‐dose PTV was comparable between the three techniques, however IMRT was statistically better for the low‐ and intermediate dose PTVs. All three techniques showed adequate orbital sparing, however OSRaT and IMRT achieved this with less under dosing of the PTVs. CONCLUSION: For the treatment of patients with advanced skin cancer of the parotid and ear, both IMRT and the OSRaT techniques are viable options. |
format | Online Article Text |
id | pubmed-5016620 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-50166202016-09-19 Conformal orbit sparing radiation therapy: a treatment option for advanced skin cancer of the parotid and ear region Foley, Heath Hopley, Shane Brown, Elizabeth Bernard, Anne Foote, Matthew J Med Radiat Sci Original Articles INTRODUCTION: New surgical methods have enabled resection of previously in‐operable tumours in the region of the parotid gland and ear. This has translated to deeper target volumes being treated with adjuvant radiotherapy. Due to the limitations of existing conformal techniques, alternative planning approaches are required to cover the target volume with appropriate sparing of adjacent critical structures. Although intensity modulated radiation therapy (IMRT) may be able to achieve these goals compared with the existing conformal method, a new orbital sparing radiation therapy (OSRaT) technique was evaluated as an alternative conformal planning process. The study objective was to evaluate the dosimetry of three planning methods: pre‐existing conformal, IMRT and OSRaT techniques. METHODS: Ten patients were planned retrospectively using the existing three‐dimensional conformal radiotherapy (3DCRT), IMRT and OSRaT techniques. Dosimetry was analysed using the homogeneity index (HI), conformity index (CI), the volume of planning target volumes (PTV) under and over treated by the 95% isodose and dose to critical structures. RESULTS: OSRaT achieved superior 95% coverage of the high‐dose PTV while delivering HI similar to IMRT for intermediate and high‐dose PTVs. The CI for the high‐dose PTV was comparable between the three techniques, however IMRT was statistically better for the low‐ and intermediate dose PTVs. All three techniques showed adequate orbital sparing, however OSRaT and IMRT achieved this with less under dosing of the PTVs. CONCLUSION: For the treatment of patients with advanced skin cancer of the parotid and ear, both IMRT and the OSRaT techniques are viable options. John Wiley and Sons Inc. 2016-03-19 2016-09 /pmc/articles/PMC5016620/ /pubmed/27648283 http://dx.doi.org/10.1002/jmrs.161 Text en © 2016 The Authors. Journal of Medical Radiation Sciences published by John Wiley & Sons Australia, Ltd on behalf of Australian Institute of Radiography and New Zealand Institute of Medical Radiation Technology. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Foley, Heath Hopley, Shane Brown, Elizabeth Bernard, Anne Foote, Matthew Conformal orbit sparing radiation therapy: a treatment option for advanced skin cancer of the parotid and ear region |
title | Conformal orbit sparing radiation therapy: a treatment option for advanced skin cancer of the parotid and ear region |
title_full | Conformal orbit sparing radiation therapy: a treatment option for advanced skin cancer of the parotid and ear region |
title_fullStr | Conformal orbit sparing radiation therapy: a treatment option for advanced skin cancer of the parotid and ear region |
title_full_unstemmed | Conformal orbit sparing radiation therapy: a treatment option for advanced skin cancer of the parotid and ear region |
title_short | Conformal orbit sparing radiation therapy: a treatment option for advanced skin cancer of the parotid and ear region |
title_sort | conformal orbit sparing radiation therapy: a treatment option for advanced skin cancer of the parotid and ear region |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016620/ https://www.ncbi.nlm.nih.gov/pubmed/27648283 http://dx.doi.org/10.1002/jmrs.161 |
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