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Conformal orbit sparing radiation therapy: a treatment option for advanced skin cancer of the parotid and ear region

INTRODUCTION: New surgical methods have enabled resection of previously in‐operable tumours in the region of the parotid gland and ear. This has translated to deeper target volumes being treated with adjuvant radiotherapy. Due to the limitations of existing conformal techniques, alternative planning...

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Autores principales: Foley, Heath, Hopley, Shane, Brown, Elizabeth, Bernard, Anne, Foote, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016620/
https://www.ncbi.nlm.nih.gov/pubmed/27648283
http://dx.doi.org/10.1002/jmrs.161
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author Foley, Heath
Hopley, Shane
Brown, Elizabeth
Bernard, Anne
Foote, Matthew
author_facet Foley, Heath
Hopley, Shane
Brown, Elizabeth
Bernard, Anne
Foote, Matthew
author_sort Foley, Heath
collection PubMed
description INTRODUCTION: New surgical methods have enabled resection of previously in‐operable tumours in the region of the parotid gland and ear. This has translated to deeper target volumes being treated with adjuvant radiotherapy. Due to the limitations of existing conformal techniques, alternative planning approaches are required to cover the target volume with appropriate sparing of adjacent critical structures. Although intensity modulated radiation therapy (IMRT) may be able to achieve these goals compared with the existing conformal method, a new orbital sparing radiation therapy (OSRaT) technique was evaluated as an alternative conformal planning process. The study objective was to evaluate the dosimetry of three planning methods: pre‐existing conformal, IMRT and OSRaT techniques. METHODS: Ten patients were planned retrospectively using the existing three‐dimensional conformal radiotherapy (3DCRT), IMRT and OSRaT techniques. Dosimetry was analysed using the homogeneity index (HI), conformity index (CI), the volume of planning target volumes (PTV) under and over treated by the 95% isodose and dose to critical structures. RESULTS: OSRaT achieved superior 95% coverage of the high‐dose PTV while delivering HI similar to IMRT for intermediate and high‐dose PTVs. The CI for the high‐dose PTV was comparable between the three techniques, however IMRT was statistically better for the low‐ and intermediate dose PTVs. All three techniques showed adequate orbital sparing, however OSRaT and IMRT achieved this with less under dosing of the PTVs. CONCLUSION: For the treatment of patients with advanced skin cancer of the parotid and ear, both IMRT and the OSRaT techniques are viable options.
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spelling pubmed-50166202016-09-19 Conformal orbit sparing radiation therapy: a treatment option for advanced skin cancer of the parotid and ear region Foley, Heath Hopley, Shane Brown, Elizabeth Bernard, Anne Foote, Matthew J Med Radiat Sci Original Articles INTRODUCTION: New surgical methods have enabled resection of previously in‐operable tumours in the region of the parotid gland and ear. This has translated to deeper target volumes being treated with adjuvant radiotherapy. Due to the limitations of existing conformal techniques, alternative planning approaches are required to cover the target volume with appropriate sparing of adjacent critical structures. Although intensity modulated radiation therapy (IMRT) may be able to achieve these goals compared with the existing conformal method, a new orbital sparing radiation therapy (OSRaT) technique was evaluated as an alternative conformal planning process. The study objective was to evaluate the dosimetry of three planning methods: pre‐existing conformal, IMRT and OSRaT techniques. METHODS: Ten patients were planned retrospectively using the existing three‐dimensional conformal radiotherapy (3DCRT), IMRT and OSRaT techniques. Dosimetry was analysed using the homogeneity index (HI), conformity index (CI), the volume of planning target volumes (PTV) under and over treated by the 95% isodose and dose to critical structures. RESULTS: OSRaT achieved superior 95% coverage of the high‐dose PTV while delivering HI similar to IMRT for intermediate and high‐dose PTVs. The CI for the high‐dose PTV was comparable between the three techniques, however IMRT was statistically better for the low‐ and intermediate dose PTVs. All three techniques showed adequate orbital sparing, however OSRaT and IMRT achieved this with less under dosing of the PTVs. CONCLUSION: For the treatment of patients with advanced skin cancer of the parotid and ear, both IMRT and the OSRaT techniques are viable options. John Wiley and Sons Inc. 2016-03-19 2016-09 /pmc/articles/PMC5016620/ /pubmed/27648283 http://dx.doi.org/10.1002/jmrs.161 Text en © 2016 The Authors. Journal of Medical Radiation Sciences published by John Wiley & Sons Australia, Ltd on behalf of Australian Institute of Radiography and New Zealand Institute of Medical Radiation Technology. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Foley, Heath
Hopley, Shane
Brown, Elizabeth
Bernard, Anne
Foote, Matthew
Conformal orbit sparing radiation therapy: a treatment option for advanced skin cancer of the parotid and ear region
title Conformal orbit sparing radiation therapy: a treatment option for advanced skin cancer of the parotid and ear region
title_full Conformal orbit sparing radiation therapy: a treatment option for advanced skin cancer of the parotid and ear region
title_fullStr Conformal orbit sparing radiation therapy: a treatment option for advanced skin cancer of the parotid and ear region
title_full_unstemmed Conformal orbit sparing radiation therapy: a treatment option for advanced skin cancer of the parotid and ear region
title_short Conformal orbit sparing radiation therapy: a treatment option for advanced skin cancer of the parotid and ear region
title_sort conformal orbit sparing radiation therapy: a treatment option for advanced skin cancer of the parotid and ear region
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016620/
https://www.ncbi.nlm.nih.gov/pubmed/27648283
http://dx.doi.org/10.1002/jmrs.161
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