Identification of a Membrane-bound Prepore Species Clarifies the Lytic Mechanism of Actinoporins

Pore-forming toxins (PFTs) are cytolytic proteins belonging to the molecular warfare apparatus of living organisms. The assembly of the functional transmembrane pore requires several intermediate steps ranging from a water-soluble monomeric species to the multimeric ensemble inserted in the cell mem...

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Detalles Bibliográficos
Autores principales: Morante, Koldo, Bellomio, Augusto, Gil-Cartón, David, Redondo-Morata, Lorena, Sot, Jesús, Scheuring, Simon, Valle, Mikel, González-Mañas, Juan Manuel, Tsumoto, Kouhei, Caaveiro, Jose M. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016661/
https://www.ncbi.nlm.nih.gov/pubmed/27445331
http://dx.doi.org/10.1074/jbc.M116.734053

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