A case of asymptomatic pancytopenia with clinical features of hemolysis as a presentation of pernicious anemia

Pernicious anemia is an autoimmune disease with a variety of clinical presentations. We describe a case of pernicious anemia presenting with pancytopenia with hemolytic features. Further workup revealed very low vitamin B12 levels and elevated methylmalonic acid. It is important for a general intern...

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Autores principales: Kollipara, Venkateswara K., Brine, Patrick L., Gemmel, David, Ingnam, Sisham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Co-Action Publishing 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016744/
https://www.ncbi.nlm.nih.gov/pubmed/27609735
http://dx.doi.org/10.3402/jchimp.v6.32493
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author Kollipara, Venkateswara K.
Brine, Patrick L.
Gemmel, David
Ingnam, Sisham
author_facet Kollipara, Venkateswara K.
Brine, Patrick L.
Gemmel, David
Ingnam, Sisham
author_sort Kollipara, Venkateswara K.
collection PubMed
description Pernicious anemia is an autoimmune disease with a variety of clinical presentations. We describe a case of pernicious anemia presenting with pancytopenia with hemolytic features. Further workup revealed very low vitamin B12 levels and elevated methylmalonic acid. It is important for a general internist to identify pernicious anemia as one of the cause of pancytopenia and hemolytic anemia to avoid extensive workup. Pernicious anemia can present strictly with hematological abnormalities without neurological problems or vice versa as in our case.
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spelling pubmed-50167442016-09-26 A case of asymptomatic pancytopenia with clinical features of hemolysis as a presentation of pernicious anemia Kollipara, Venkateswara K. Brine, Patrick L. Gemmel, David Ingnam, Sisham J Community Hosp Intern Med Perspect Case Report Pernicious anemia is an autoimmune disease with a variety of clinical presentations. We describe a case of pernicious anemia presenting with pancytopenia with hemolytic features. Further workup revealed very low vitamin B12 levels and elevated methylmalonic acid. It is important for a general internist to identify pernicious anemia as one of the cause of pancytopenia and hemolytic anemia to avoid extensive workup. Pernicious anemia can present strictly with hematological abnormalities without neurological problems or vice versa as in our case. Co-Action Publishing 2016-09-07 /pmc/articles/PMC5016744/ /pubmed/27609735 http://dx.doi.org/10.3402/jchimp.v6.32493 Text en © 2016 Venkateswara K. Kollipara et al. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kollipara, Venkateswara K.
Brine, Patrick L.
Gemmel, David
Ingnam, Sisham
A case of asymptomatic pancytopenia with clinical features of hemolysis as a presentation of pernicious anemia
title A case of asymptomatic pancytopenia with clinical features of hemolysis as a presentation of pernicious anemia
title_full A case of asymptomatic pancytopenia with clinical features of hemolysis as a presentation of pernicious anemia
title_fullStr A case of asymptomatic pancytopenia with clinical features of hemolysis as a presentation of pernicious anemia
title_full_unstemmed A case of asymptomatic pancytopenia with clinical features of hemolysis as a presentation of pernicious anemia
title_short A case of asymptomatic pancytopenia with clinical features of hemolysis as a presentation of pernicious anemia
title_sort case of asymptomatic pancytopenia with clinical features of hemolysis as a presentation of pernicious anemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016744/
https://www.ncbi.nlm.nih.gov/pubmed/27609735
http://dx.doi.org/10.3402/jchimp.v6.32493
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