Development of a Cell-penetrating Peptide that Exhibits Responsive Changes in its Secondary Structure in the Cellular Environment

Cell-penetrating peptides (CPP) are received a lot of attention as an intracellular delivery tool for hydrophilic molecules such as drugs, proteins, and DNAs. We designed and synthesized nona-arginine analogues 1–5 [FAM-β-Ala-(l-Arg-l-Arg-l-Pro)(3)-(Gly)(3)-NH(2) (1), FAM-β-Ala-(l-Arg-l-Arg-l-Pro(NH...

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Detalles Bibliográficos
Autores principales: Yamashita, Hiroko, Kato, Takuma, Oba, Makoto, Misawa, Takashi, Hattori, Takayuki, Ohoka, Nobumichi, Tanaka, Masakazu, Naito, Mikihiko, Kurihara, Masaaki, Demizu, Yosuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016780/
https://www.ncbi.nlm.nih.gov/pubmed/27609319
http://dx.doi.org/10.1038/srep33003

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