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Interaction of MSC with tumor cells
Tumor development and tumor progression is not only determined by the corresponding tumor cells but also by the tumor microenvironment. This includes an orchestrated network of interacting cell types (e.g. immune cells, endothelial cells, fibroblasts, and mesenchymal stroma/stem cells (MSC)) via the...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016940/ https://www.ncbi.nlm.nih.gov/pubmed/27608835 http://dx.doi.org/10.1186/s12964-016-0143-0 |
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author | Melzer, Catharina Yang, Yuanyuan Hass, Ralf |
author_facet | Melzer, Catharina Yang, Yuanyuan Hass, Ralf |
author_sort | Melzer, Catharina |
collection | PubMed |
description | Tumor development and tumor progression is not only determined by the corresponding tumor cells but also by the tumor microenvironment. This includes an orchestrated network of interacting cell types (e.g. immune cells, endothelial cells, fibroblasts, and mesenchymal stroma/stem cells (MSC)) via the extracellular matrix and soluble factors such as cytokines, chemokines, growth factors and various metabolites. Cell populations of the tumor microenvironment can interact directly and indirectly with cancer cells by mutually altering properties and functions of the involved partners. Particularly, mesenchymal stroma/stem cells (MSC) play an important role during carcinogenesis exhibiting different types of intercellular communication. Accordingly, this work focusses on diverse mechanisms of interaction between MSC and cancer cells. Moreover, some functional changes and consequences for both cell types are summarized which can eventually result in the establishment of a carcinoma stem cell niche (CSCN) or the generation of new tumor cell populations by MSC-tumor cell fusion. |
format | Online Article Text |
id | pubmed-5016940 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-50169402016-09-10 Interaction of MSC with tumor cells Melzer, Catharina Yang, Yuanyuan Hass, Ralf Cell Commun Signal Review Tumor development and tumor progression is not only determined by the corresponding tumor cells but also by the tumor microenvironment. This includes an orchestrated network of interacting cell types (e.g. immune cells, endothelial cells, fibroblasts, and mesenchymal stroma/stem cells (MSC)) via the extracellular matrix and soluble factors such as cytokines, chemokines, growth factors and various metabolites. Cell populations of the tumor microenvironment can interact directly and indirectly with cancer cells by mutually altering properties and functions of the involved partners. Particularly, mesenchymal stroma/stem cells (MSC) play an important role during carcinogenesis exhibiting different types of intercellular communication. Accordingly, this work focusses on diverse mechanisms of interaction between MSC and cancer cells. Moreover, some functional changes and consequences for both cell types are summarized which can eventually result in the establishment of a carcinoma stem cell niche (CSCN) or the generation of new tumor cell populations by MSC-tumor cell fusion. BioMed Central 2016-09-08 /pmc/articles/PMC5016940/ /pubmed/27608835 http://dx.doi.org/10.1186/s12964-016-0143-0 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Melzer, Catharina Yang, Yuanyuan Hass, Ralf Interaction of MSC with tumor cells |
title | Interaction of MSC with tumor cells |
title_full | Interaction of MSC with tumor cells |
title_fullStr | Interaction of MSC with tumor cells |
title_full_unstemmed | Interaction of MSC with tumor cells |
title_short | Interaction of MSC with tumor cells |
title_sort | interaction of msc with tumor cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016940/ https://www.ncbi.nlm.nih.gov/pubmed/27608835 http://dx.doi.org/10.1186/s12964-016-0143-0 |
work_keys_str_mv | AT melzercatharina interactionofmscwithtumorcells AT yangyuanyuan interactionofmscwithtumorcells AT hassralf interactionofmscwithtumorcells |