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Essential functions linked with structural disorder in organisms of minimal genome

ABSTRACT: Intrinsically disordered regions (IDRs) of proteins fulfill important regulatory roles in most organisms. However, the proteins of certain endosymbiont and intracellular pathogenic bacteria with extremely reduced genomes contain disproportionately small amounts of IDRs, consisting almost e...

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Autores principales: Pancsa, Rita, Tompa, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016991/
https://www.ncbi.nlm.nih.gov/pubmed/27608806
http://dx.doi.org/10.1186/s13062-016-0149-y
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author Pancsa, Rita
Tompa, Peter
author_facet Pancsa, Rita
Tompa, Peter
author_sort Pancsa, Rita
collection PubMed
description ABSTRACT: Intrinsically disordered regions (IDRs) of proteins fulfill important regulatory roles in most organisms. However, the proteins of certain endosymbiont and intracellular pathogenic bacteria with extremely reduced genomes contain disproportionately small amounts of IDRs, consisting almost entirely of folded domains. As their genomes co-evolving with their hosts have been reduced in unrelated lineages, the proteomes of these bacteria represent independently evolved minimal protein sets. We systematically analyzed structural disorder in a representative set of such minimal organisms to see which types of functionally relevant longer IDRs are invariably retained in them. We found that a few characteristic functions are consistently linked with conformational disorder: ribosomal proteins, key components of the protein production machinery, a central coordinator of DNA metabolism and certain housekeeping chaperones seem to strictly rely on structural disorder even in genome-reduced organisms. We propose that these functions correspond to the most essential and probably also the most ancient ones fulfilled by structural disorder in cellular organisms. REVIEWERS: This article was reviewed by Michael Gromiha, Zoltan Gaspari and Sandor Pongor. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13062-016-0149-y) contains supplementary material, which is available to authorized users.
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spelling pubmed-50169912016-09-10 Essential functions linked with structural disorder in organisms of minimal genome Pancsa, Rita Tompa, Peter Biol Direct Discovery Notes ABSTRACT: Intrinsically disordered regions (IDRs) of proteins fulfill important regulatory roles in most organisms. However, the proteins of certain endosymbiont and intracellular pathogenic bacteria with extremely reduced genomes contain disproportionately small amounts of IDRs, consisting almost entirely of folded domains. As their genomes co-evolving with their hosts have been reduced in unrelated lineages, the proteomes of these bacteria represent independently evolved minimal protein sets. We systematically analyzed structural disorder in a representative set of such minimal organisms to see which types of functionally relevant longer IDRs are invariably retained in them. We found that a few characteristic functions are consistently linked with conformational disorder: ribosomal proteins, key components of the protein production machinery, a central coordinator of DNA metabolism and certain housekeeping chaperones seem to strictly rely on structural disorder even in genome-reduced organisms. We propose that these functions correspond to the most essential and probably also the most ancient ones fulfilled by structural disorder in cellular organisms. REVIEWERS: This article was reviewed by Michael Gromiha, Zoltan Gaspari and Sandor Pongor. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13062-016-0149-y) contains supplementary material, which is available to authorized users. BioMed Central 2016-09-08 /pmc/articles/PMC5016991/ /pubmed/27608806 http://dx.doi.org/10.1186/s13062-016-0149-y Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Discovery Notes
Pancsa, Rita
Tompa, Peter
Essential functions linked with structural disorder in organisms of minimal genome
title Essential functions linked with structural disorder in organisms of minimal genome
title_full Essential functions linked with structural disorder in organisms of minimal genome
title_fullStr Essential functions linked with structural disorder in organisms of minimal genome
title_full_unstemmed Essential functions linked with structural disorder in organisms of minimal genome
title_short Essential functions linked with structural disorder in organisms of minimal genome
title_sort essential functions linked with structural disorder in organisms of minimal genome
topic Discovery Notes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016991/
https://www.ncbi.nlm.nih.gov/pubmed/27608806
http://dx.doi.org/10.1186/s13062-016-0149-y
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