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Corneal Collagen Cross Linking (CXL) in treatment of Pseudophakic Bullous Keratopathy

OBJECTIVE: To determine mean change in visual acuity, central corneal thickness and symptoms in patients with pseudophakic bullous keratopathy after treatment with corneal collagen crosslinking. METHODS: This quasi experimental study was conducted at Armed Forces Institute of Ophthalmology, Rawalpin...

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Autores principales: Khan, Muhammad Saim, Basit, Imran, Ishaq, Mazhar, Shakoor, Tariq, Yaqub, Amer, Intisar, Rana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Professional Medical Publications 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017112/
https://www.ncbi.nlm.nih.gov/pubmed/27648049
http://dx.doi.org/10.12669/pjms.324.10138
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author Khan, Muhammad Saim
Basit, Imran
Ishaq, Mazhar
Shakoor, Tariq
Yaqub, Amer
Intisar, Rana
author_facet Khan, Muhammad Saim
Basit, Imran
Ishaq, Mazhar
Shakoor, Tariq
Yaqub, Amer
Intisar, Rana
author_sort Khan, Muhammad Saim
collection PubMed
description OBJECTIVE: To determine mean change in visual acuity, central corneal thickness and symptoms in patients with pseudophakic bullous keratopathy after treatment with corneal collagen crosslinking. METHODS: This quasi experimental study was conducted at Armed Forces Institute of Ophthalmology, Rawalpindi, Pakistan from April 2015 to Nov 2015. A total of 24 eyes of 24 patients were included in the study. Visual symptoms were graded in five grades (Grade 1-5), Grade-1 being very mild with decreased vision only while patients with all five symptoms (decreased vision, foreign body sensations, pain, watering and photophobia) were graded as Grade-5. Corneal collagen cross linking using topical isotonic riboflavin followed by UVA radiations (3mW/cm(2) for 10 minutes) was performed in all the patients. Visual acuity (VA), visual symptoms and central corneal thickness (CCT) were recorded before and 04 weeks after the treatment. RESULTS: A total of 24 eyes of 24 patients (18 male and 6 females) underwent surgery. Age of the patients ranged from 55 to 75 years with mean age 65.83 + 3.89 years. Mean visual acuity was 2.09 + 0.23 before treatment while after treatment it was 2.13 + 0.22. Mean CCT as measured by optical pachymetry (Galilae G6) was 753.96 + 55.16 and 641+ 29.25 before and after surgery respectively. Improvement of clinical symptoms was seen in all the patients. CONCLUSION: Corneal collagen cross linking is a temporary but effective symptomatic treatment of pseudophakic bullous keratopathy.
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spelling pubmed-50171122016-09-19 Corneal Collagen Cross Linking (CXL) in treatment of Pseudophakic Bullous Keratopathy Khan, Muhammad Saim Basit, Imran Ishaq, Mazhar Shakoor, Tariq Yaqub, Amer Intisar, Rana Pak J Med Sci Original Article OBJECTIVE: To determine mean change in visual acuity, central corneal thickness and symptoms in patients with pseudophakic bullous keratopathy after treatment with corneal collagen crosslinking. METHODS: This quasi experimental study was conducted at Armed Forces Institute of Ophthalmology, Rawalpindi, Pakistan from April 2015 to Nov 2015. A total of 24 eyes of 24 patients were included in the study. Visual symptoms were graded in five grades (Grade 1-5), Grade-1 being very mild with decreased vision only while patients with all five symptoms (decreased vision, foreign body sensations, pain, watering and photophobia) were graded as Grade-5. Corneal collagen cross linking using topical isotonic riboflavin followed by UVA radiations (3mW/cm(2) for 10 minutes) was performed in all the patients. Visual acuity (VA), visual symptoms and central corneal thickness (CCT) were recorded before and 04 weeks after the treatment. RESULTS: A total of 24 eyes of 24 patients (18 male and 6 females) underwent surgery. Age of the patients ranged from 55 to 75 years with mean age 65.83 + 3.89 years. Mean visual acuity was 2.09 + 0.23 before treatment while after treatment it was 2.13 + 0.22. Mean CCT as measured by optical pachymetry (Galilae G6) was 753.96 + 55.16 and 641+ 29.25 before and after surgery respectively. Improvement of clinical symptoms was seen in all the patients. CONCLUSION: Corneal collagen cross linking is a temporary but effective symptomatic treatment of pseudophakic bullous keratopathy. Professional Medical Publications 2016 /pmc/articles/PMC5017112/ /pubmed/27648049 http://dx.doi.org/10.12669/pjms.324.10138 Text en Copyright: © Pakistan Journal of Medical Sciences http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Khan, Muhammad Saim
Basit, Imran
Ishaq, Mazhar
Shakoor, Tariq
Yaqub, Amer
Intisar, Rana
Corneal Collagen Cross Linking (CXL) in treatment of Pseudophakic Bullous Keratopathy
title Corneal Collagen Cross Linking (CXL) in treatment of Pseudophakic Bullous Keratopathy
title_full Corneal Collagen Cross Linking (CXL) in treatment of Pseudophakic Bullous Keratopathy
title_fullStr Corneal Collagen Cross Linking (CXL) in treatment of Pseudophakic Bullous Keratopathy
title_full_unstemmed Corneal Collagen Cross Linking (CXL) in treatment of Pseudophakic Bullous Keratopathy
title_short Corneal Collagen Cross Linking (CXL) in treatment of Pseudophakic Bullous Keratopathy
title_sort corneal collagen cross linking (cxl) in treatment of pseudophakic bullous keratopathy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017112/
https://www.ncbi.nlm.nih.gov/pubmed/27648049
http://dx.doi.org/10.12669/pjms.324.10138
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