Temperature-sensitive gating of TRPV1 channel as probed by atomistic simulations of its trans- and juxtamembrane domains

Heat-activated transient receptor potential channel TRPV1 is one of the most studied eukaryotic proteins involved in temperature sensation. Upon heating, it exhibits rapid reversible pore gating, which depolarizes neurons and generates action potentials. Underlying molecular details of such effects...

Descripción completa

Detalles Bibliográficos
Autores principales: Chugunov, Anton O., Volynsky, Pavel E., Krylov, Nikolay A., Nolde, Dmitry E., Efremov, Roman G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017144/
https://www.ncbi.nlm.nih.gov/pubmed/27612191
http://dx.doi.org/10.1038/srep33112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017144/
https://www.ncbi.nlm.nih.gov/pubmed/27612191
http://dx.doi.org/10.1038/srep33112

Ejemplares similares