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The serotonergic system and cognitive function

Symptoms of cognitive dysfunction like memory loss, poor concentration, impaired learning and executive functions are characteristic features of both schizophrenia and Alzheimer’s disease (AD). The neurobiological mechanisms underlying cognition in healthy subjects and neuropsychiatric patients are...

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Autores principales: Švob Štrac, Dubravka, Pivac, Nela, Mück-Šeler, Dorotea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017596/
https://www.ncbi.nlm.nih.gov/pubmed/28123820
http://dx.doi.org/10.1515/tnsci-2016-0007
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author Švob Štrac, Dubravka
Pivac, Nela
Mück-Šeler, Dorotea
author_facet Švob Štrac, Dubravka
Pivac, Nela
Mück-Šeler, Dorotea
author_sort Švob Štrac, Dubravka
collection PubMed
description Symptoms of cognitive dysfunction like memory loss, poor concentration, impaired learning and executive functions are characteristic features of both schizophrenia and Alzheimer’s disease (AD). The neurobiological mechanisms underlying cognition in healthy subjects and neuropsychiatric patients are not completely understood. Studies have focused on serotonin (5-hydroxytryptamine, 5-HT) as one of the possible cognitionrelated biomarkers. The aim of this review is to provide a summary of the current literature on the role of the serotonergic (5-HTergic) system in cognitive function, particularly in AD and schizophrenia. The role of the 5-HTergic system in cognition is modulated by the activity and function of 5-HT receptors (5-HTR) classified into seven groups, which differ in structure, action, and localization. Many 5-HTR are located in the regions linked to various cognitive processes. Preclinical studies using animal models of learning and memory, as well as clinical in vivo (neuroimaging) and in vitro (post-mortem) studies in humans have shown that alterations in 5-HTR activity influence cognitive performance. The current evidence implies that reduced 5-HT neurotransmission negatively influences cognitive functions and that normalization of 5-HT activity may have beneficial effects, suggesting that 5-HT and 5-HTR represent important pharmacological targets for cognition enhancement and restoration of impaired cognitive performance in neuropsychiatric disorders.
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spelling pubmed-50175962017-01-25 The serotonergic system and cognitive function Švob Štrac, Dubravka Pivac, Nela Mück-Šeler, Dorotea Transl Neurosci Review Article Symptoms of cognitive dysfunction like memory loss, poor concentration, impaired learning and executive functions are characteristic features of both schizophrenia and Alzheimer’s disease (AD). The neurobiological mechanisms underlying cognition in healthy subjects and neuropsychiatric patients are not completely understood. Studies have focused on serotonin (5-hydroxytryptamine, 5-HT) as one of the possible cognitionrelated biomarkers. The aim of this review is to provide a summary of the current literature on the role of the serotonergic (5-HTergic) system in cognitive function, particularly in AD and schizophrenia. The role of the 5-HTergic system in cognition is modulated by the activity and function of 5-HT receptors (5-HTR) classified into seven groups, which differ in structure, action, and localization. Many 5-HTR are located in the regions linked to various cognitive processes. Preclinical studies using animal models of learning and memory, as well as clinical in vivo (neuroimaging) and in vitro (post-mortem) studies in humans have shown that alterations in 5-HTR activity influence cognitive performance. The current evidence implies that reduced 5-HT neurotransmission negatively influences cognitive functions and that normalization of 5-HT activity may have beneficial effects, suggesting that 5-HT and 5-HTR represent important pharmacological targets for cognition enhancement and restoration of impaired cognitive performance in neuropsychiatric disorders. De Gruyter 2016-05-09 /pmc/articles/PMC5017596/ /pubmed/28123820 http://dx.doi.org/10.1515/tnsci-2016-0007 Text en © 2016 Dubravka Švob Štrac et al., published by De Gruyter Open http://creativecommons.org/licenses/by-nc-nd/3.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
spellingShingle Review Article
Švob Štrac, Dubravka
Pivac, Nela
Mück-Šeler, Dorotea
The serotonergic system and cognitive function
title The serotonergic system and cognitive function
title_full The serotonergic system and cognitive function
title_fullStr The serotonergic system and cognitive function
title_full_unstemmed The serotonergic system and cognitive function
title_short The serotonergic system and cognitive function
title_sort serotonergic system and cognitive function
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017596/
https://www.ncbi.nlm.nih.gov/pubmed/28123820
http://dx.doi.org/10.1515/tnsci-2016-0007
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