Faster DNA Repair of Ultraviolet-Induced Cyclobutane Pyrimidine Dimers and Lower Sensitivity to Apoptosis in Human Corneal Epithelial Cells than in Epidermal Keratinocytes

Absorption of UV rays by DNA generates the formation of mutagenic cyclobutane pyrimidine dimers (CPD) and pyrimidine (6–4) pyrimidone photoproducts (6-4PP). These damages are the major cause of skin cancer because in turn, they can lead to signature UV mutations. The eye is exposed to UV light, but...

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Detalles Bibliográficos
Autores principales: Mallet, Justin D., Dorr, Marie M., Drigeard Desgarnier, Marie-Catherine, Bastien, Nathalie, Gendron, Sébastien P., Rochette, Patrick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017652/
https://www.ncbi.nlm.nih.gov/pubmed/27611318
http://dx.doi.org/10.1371/journal.pone.0162212

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017652/
https://www.ncbi.nlm.nih.gov/pubmed/27611318
http://dx.doi.org/10.1371/journal.pone.0162212

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