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Faster DNA Repair of Ultraviolet-Induced Cyclobutane Pyrimidine Dimers and Lower Sensitivity to Apoptosis in Human Corneal Epithelial Cells than in Epidermal Keratinocytes
Absorption of UV rays by DNA generates the formation of mutagenic cyclobutane pyrimidine dimers (CPD) and pyrimidine (6–4) pyrimidone photoproducts (6-4PP). These damages are the major cause of skin cancer because in turn, they can lead to signature UV mutations. The eye is exposed to UV light, but...
Autores principales: | Mallet, Justin D., Dorr, Marie M., Drigeard Desgarnier, Marie-Catherine, Bastien, Nathalie, Gendron, Sébastien P., Rochette, Patrick J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017652/ https://www.ncbi.nlm.nih.gov/pubmed/27611318 http://dx.doi.org/10.1371/journal.pone.0162212 |
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