Identification of Gastric Cancer Biomarkers Using (1)H Nuclear Magnetic Resonance Spectrometry

Existing gastric cancer diagnosing methods were invasive, hence, a reliable non-invasive gastric cancer diagnosing method is needed. As a starting point, we used 1H NMR for identifying gastric cancer biomarkers using a panel of gastric cancer spheroids and normal gastric spheroids. We were able to i...

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Detalles Bibliográficos
Autores principales: Ramachandran, Gokula Krishnan, Yong, Wei Peng, Yeow, Chen Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017672/
https://www.ncbi.nlm.nih.gov/pubmed/27611679
http://dx.doi.org/10.1371/journal.pone.0162222
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author Ramachandran, Gokula Krishnan
Yong, Wei Peng
Yeow, Chen Hua
author_facet Ramachandran, Gokula Krishnan
Yong, Wei Peng
Yeow, Chen Hua
author_sort Ramachandran, Gokula Krishnan
collection PubMed
description Existing gastric cancer diagnosing methods were invasive, hence, a reliable non-invasive gastric cancer diagnosing method is needed. As a starting point, we used 1H NMR for identifying gastric cancer biomarkers using a panel of gastric cancer spheroids and normal gastric spheroids. We were able to identify 8 chemical shift biomarkers for gastric cancer spheroids. Our data suggests that the cancerous and non-cancerous spheroids significantly differ in the lipid composition and energy metabolism. These results encourage the translation of these biomarkers into in-vivo gastric cancer detection methodology using MRI-MS.
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spelling pubmed-50176722016-09-27 Identification of Gastric Cancer Biomarkers Using (1)H Nuclear Magnetic Resonance Spectrometry Ramachandran, Gokula Krishnan Yong, Wei Peng Yeow, Chen Hua PLoS One Research Article Existing gastric cancer diagnosing methods were invasive, hence, a reliable non-invasive gastric cancer diagnosing method is needed. As a starting point, we used 1H NMR for identifying gastric cancer biomarkers using a panel of gastric cancer spheroids and normal gastric spheroids. We were able to identify 8 chemical shift biomarkers for gastric cancer spheroids. Our data suggests that the cancerous and non-cancerous spheroids significantly differ in the lipid composition and energy metabolism. These results encourage the translation of these biomarkers into in-vivo gastric cancer detection methodology using MRI-MS. Public Library of Science 2016-09-09 /pmc/articles/PMC5017672/ /pubmed/27611679 http://dx.doi.org/10.1371/journal.pone.0162222 Text en © 2016 Ramachandran et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ramachandran, Gokula Krishnan
Yong, Wei Peng
Yeow, Chen Hua
Identification of Gastric Cancer Biomarkers Using (1)H Nuclear Magnetic Resonance Spectrometry
title Identification of Gastric Cancer Biomarkers Using (1)H Nuclear Magnetic Resonance Spectrometry
title_full Identification of Gastric Cancer Biomarkers Using (1)H Nuclear Magnetic Resonance Spectrometry
title_fullStr Identification of Gastric Cancer Biomarkers Using (1)H Nuclear Magnetic Resonance Spectrometry
title_full_unstemmed Identification of Gastric Cancer Biomarkers Using (1)H Nuclear Magnetic Resonance Spectrometry
title_short Identification of Gastric Cancer Biomarkers Using (1)H Nuclear Magnetic Resonance Spectrometry
title_sort identification of gastric cancer biomarkers using (1)h nuclear magnetic resonance spectrometry
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017672/
https://www.ncbi.nlm.nih.gov/pubmed/27611679
http://dx.doi.org/10.1371/journal.pone.0162222
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AT yeowchenhua identificationofgastriccancerbiomarkersusing1hnuclearmagneticresonancespectrometry

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