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One Odontogenic Cell-Population Contributes to the Development of the Mouse Incisors and of the Oral Vestibule

The area of the oral vestibule is often a place where pathologies appear (e.g., peripheral odontomas). The origin of these pathologies is not fully understood. In the present study, we traced a cell population expressing Sonic hedgehog (Shh) from the beginning of tooth development using Cre-LoxP sys...

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Autores principales: Hovorakova, Maria, Lochovska, Katerina, Zahradnicek, Oldrich, Domonkosova Tibenska, Kristina, Dornhoferova, Michaela, Horakova-Smrckova, Lucie, Bodorikova, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017683/
https://www.ncbi.nlm.nih.gov/pubmed/27611193
http://dx.doi.org/10.1371/journal.pone.0162523
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author Hovorakova, Maria
Lochovska, Katerina
Zahradnicek, Oldrich
Domonkosova Tibenska, Kristina
Dornhoferova, Michaela
Horakova-Smrckova, Lucie
Bodorikova, Silvia
author_facet Hovorakova, Maria
Lochovska, Katerina
Zahradnicek, Oldrich
Domonkosova Tibenska, Kristina
Dornhoferova, Michaela
Horakova-Smrckova, Lucie
Bodorikova, Silvia
author_sort Hovorakova, Maria
collection PubMed
description The area of the oral vestibule is often a place where pathologies appear (e.g., peripheral odontomas). The origin of these pathologies is not fully understood. In the present study, we traced a cell population expressing Sonic hedgehog (Shh) from the beginning of tooth development using Cre-LoxP system in the lower jaw of wild-type (WT) mice. We focused on Shh expression in the area of the early appearing rudimentary incisor germs located anteriorly to the prospective incisors. The localization of the labelled cells in the incisor germs and also in the inner epithelial layer of the vestibular anlage showed that the first very early developmental events in the lower incisor area are common to the vestibulum oris and the prospective incisor primordia in mice. Scanning electron microscopic analysis of human historical tooth-like structures found in the vestibular area of jaws confirmed their relation to teeth and thus the capability of the vestibular tissue to form teeth. The location of labelled cells descendant of the early appearing Shh expression domain related to the rudimentary incisor anlage not only in the rudimentary and functional incisor germs but also in the externally located anlage of the oral vestibule documented the odontogenic potential of the vestibular epithelium. This potential can be awakened under pathological conditions and become a source of pathologies in the vestibular area.
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spelling pubmed-50176832016-09-27 One Odontogenic Cell-Population Contributes to the Development of the Mouse Incisors and of the Oral Vestibule Hovorakova, Maria Lochovska, Katerina Zahradnicek, Oldrich Domonkosova Tibenska, Kristina Dornhoferova, Michaela Horakova-Smrckova, Lucie Bodorikova, Silvia PLoS One Research Article The area of the oral vestibule is often a place where pathologies appear (e.g., peripheral odontomas). The origin of these pathologies is not fully understood. In the present study, we traced a cell population expressing Sonic hedgehog (Shh) from the beginning of tooth development using Cre-LoxP system in the lower jaw of wild-type (WT) mice. We focused on Shh expression in the area of the early appearing rudimentary incisor germs located anteriorly to the prospective incisors. The localization of the labelled cells in the incisor germs and also in the inner epithelial layer of the vestibular anlage showed that the first very early developmental events in the lower incisor area are common to the vestibulum oris and the prospective incisor primordia in mice. Scanning electron microscopic analysis of human historical tooth-like structures found in the vestibular area of jaws confirmed their relation to teeth and thus the capability of the vestibular tissue to form teeth. The location of labelled cells descendant of the early appearing Shh expression domain related to the rudimentary incisor anlage not only in the rudimentary and functional incisor germs but also in the externally located anlage of the oral vestibule documented the odontogenic potential of the vestibular epithelium. This potential can be awakened under pathological conditions and become a source of pathologies in the vestibular area. Public Library of Science 2016-09-09 /pmc/articles/PMC5017683/ /pubmed/27611193 http://dx.doi.org/10.1371/journal.pone.0162523 Text en © 2016 Hovorakova et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Hovorakova, Maria
Lochovska, Katerina
Zahradnicek, Oldrich
Domonkosova Tibenska, Kristina
Dornhoferova, Michaela
Horakova-Smrckova, Lucie
Bodorikova, Silvia
One Odontogenic Cell-Population Contributes to the Development of the Mouse Incisors and of the Oral Vestibule
title One Odontogenic Cell-Population Contributes to the Development of the Mouse Incisors and of the Oral Vestibule
title_full One Odontogenic Cell-Population Contributes to the Development of the Mouse Incisors and of the Oral Vestibule
title_fullStr One Odontogenic Cell-Population Contributes to the Development of the Mouse Incisors and of the Oral Vestibule
title_full_unstemmed One Odontogenic Cell-Population Contributes to the Development of the Mouse Incisors and of the Oral Vestibule
title_short One Odontogenic Cell-Population Contributes to the Development of the Mouse Incisors and of the Oral Vestibule
title_sort one odontogenic cell-population contributes to the development of the mouse incisors and of the oral vestibule
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017683/
https://www.ncbi.nlm.nih.gov/pubmed/27611193
http://dx.doi.org/10.1371/journal.pone.0162523
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