Sensitive methods for screening of the MEK1 gene mutations in patients with central nervous system metastases of non-small cell lung cancer

BACKGROUND: The mitogen-activated protein kinases 1 and 2 (MEK1, MEK2) are fundamental partners in the RAS–RAF–MEK–ERK pathway that is involved in regulation of cell proliferation, differentiation and survival. Downregulation of the MEK cascades has been implicated in acquiring of the malignant phen...

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Detalles Bibliográficos
Autores principales: Nicoś, M., Krawczyk, P., Jarosz, B., Sawicki, M., Michnar, M., Trojanowski, T., Milanowski, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018022/
https://www.ncbi.nlm.nih.gov/pubmed/26860843
http://dx.doi.org/10.1007/s12094-016-1483-3

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