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The Role of Caffeine in Pain Management: A Brief Literature Review
CONTEXT: Caffeine is the most commonly used psychoactive legal drug in the world. Caffeine’s role in controlling pain has received less attention in the past, yet is being increasingly considered. This article briefly reviewed the literature to clarify the role of caffeine as a drug for pain control...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Kowsar
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018099/ https://www.ncbi.nlm.nih.gov/pubmed/27642573 http://dx.doi.org/10.5812/aapm.33193 |
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author | Baratloo, Alireza Rouhipour, Alaleh Forouzanfar, Mohammad Mehdi Safari, Saeed Amiri, Marzieh Negida, Ahmed |
author_facet | Baratloo, Alireza Rouhipour, Alaleh Forouzanfar, Mohammad Mehdi Safari, Saeed Amiri, Marzieh Negida, Ahmed |
author_sort | Baratloo, Alireza |
collection | PubMed |
description | CONTEXT: Caffeine is the most commonly used psychoactive legal drug in the world. Caffeine’s role in controlling pain has received less attention in the past, yet is being increasingly considered. This article briefly reviewed the literature to clarify the role of caffeine as a drug for pain control and attract investigators to this topic. EVIDENCE ACQUISITION: The data on Caffeine as an adjuvant therapy or as a main component for pain modulation has been narratively reviewed. RESULTS: Caffeine plays an important role in pain modulation through their action on adenosine receptors which are involved in nociception. The use of caffeine as adjuvant treatment was well-established in the literature and caffeine is currently available in some over the counter medications. Studies showed controversial results about the interaction between caffeine and morphine for pain relief in patients with terminal stage cancer. As a main component for pain modulation, Caffeine can be used for hypnic headache and postdural puncture headache. CONCLUSIONS: Caffeine has a potential role for pain modulation. Current evidence on caffeine use for migraine and terminal stage cancer is not well-established. Future studies should address the use of caffeine alone for different types of pain with dose escalation and standardization of outcome measurement. |
format | Online Article Text |
id | pubmed-5018099 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Kowsar |
record_format | MEDLINE/PubMed |
spelling | pubmed-50180992016-09-16 The Role of Caffeine in Pain Management: A Brief Literature Review Baratloo, Alireza Rouhipour, Alaleh Forouzanfar, Mohammad Mehdi Safari, Saeed Amiri, Marzieh Negida, Ahmed Anesth Pain Med Review Article CONTEXT: Caffeine is the most commonly used psychoactive legal drug in the world. Caffeine’s role in controlling pain has received less attention in the past, yet is being increasingly considered. This article briefly reviewed the literature to clarify the role of caffeine as a drug for pain control and attract investigators to this topic. EVIDENCE ACQUISITION: The data on Caffeine as an adjuvant therapy or as a main component for pain modulation has been narratively reviewed. RESULTS: Caffeine plays an important role in pain modulation through their action on adenosine receptors which are involved in nociception. The use of caffeine as adjuvant treatment was well-established in the literature and caffeine is currently available in some over the counter medications. Studies showed controversial results about the interaction between caffeine and morphine for pain relief in patients with terminal stage cancer. As a main component for pain modulation, Caffeine can be used for hypnic headache and postdural puncture headache. CONCLUSIONS: Caffeine has a potential role for pain modulation. Current evidence on caffeine use for migraine and terminal stage cancer is not well-established. Future studies should address the use of caffeine alone for different types of pain with dose escalation and standardization of outcome measurement. Kowsar 2016-03-26 /pmc/articles/PMC5018099/ /pubmed/27642573 http://dx.doi.org/10.5812/aapm.33193 Text en Copyright © 2016, Iranian Society of Regional Anesthesia and Pain Medicine (ISRAPM). http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited. |
spellingShingle | Review Article Baratloo, Alireza Rouhipour, Alaleh Forouzanfar, Mohammad Mehdi Safari, Saeed Amiri, Marzieh Negida, Ahmed The Role of Caffeine in Pain Management: A Brief Literature Review |
title | The Role of Caffeine in Pain Management: A Brief Literature Review |
title_full | The Role of Caffeine in Pain Management: A Brief Literature Review |
title_fullStr | The Role of Caffeine in Pain Management: A Brief Literature Review |
title_full_unstemmed | The Role of Caffeine in Pain Management: A Brief Literature Review |
title_short | The Role of Caffeine in Pain Management: A Brief Literature Review |
title_sort | role of caffeine in pain management: a brief literature review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018099/ https://www.ncbi.nlm.nih.gov/pubmed/27642573 http://dx.doi.org/10.5812/aapm.33193 |
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