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Tectorial Membrane Traveling Waves Underlie Sharp Auditory Tuning in Humans

Our ability to understand speech requires neural tuning with high frequency resolution, but the peripheral mechanisms underlying sharp tuning in humans remain unclear. Sharp tuning in genetically modified mice has been attributed to decreases in spread of excitation of tectorial membrane traveling w...

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Detalles Bibliográficos
Autores principales: Farrahi, Shirin, Ghaffari, Roozbeh, Sellon, Jonathan B., Nakajima, Hideko H., Freeman, Dennis M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018139/
https://www.ncbi.nlm.nih.gov/pubmed/27544000
http://dx.doi.org/10.1016/j.bpj.2016.07.038
Descripción
Sumario:Our ability to understand speech requires neural tuning with high frequency resolution, but the peripheral mechanisms underlying sharp tuning in humans remain unclear. Sharp tuning in genetically modified mice has been attributed to decreases in spread of excitation of tectorial membrane traveling waves. Here we show that the spread of excitation of tectorial membrane waves is similar in humans and mice, although the mechanical excitation spans fewer frequencies in humans—suggesting a possible mechanism for sharper tuning.