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Effect of Preoperative Oral Amantadine on Acute and Chronic Postoperative Pain After Mandibular Fracture Surgery

BACKGROUND: Postoperative pain from open reduction and internal fixation of mandibular fracture is a serious issue. Amantadine is an N-methyl-D-aspartic acid or N-methyl-D-aspartate (NMDA) receptor antagonist that can be effective against postoperative pain. OBJECTIVES: The present study examined th...

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Autores principales: Yazdani, Javad, Aghamohamadi, Davood, Amani, Masoomeh, Mesgarzadeh, Ali Hossein, Maghbooli Asl, Davood, Pourlak, Tannaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018158/
https://www.ncbi.nlm.nih.gov/pubmed/27642581
http://dx.doi.org/10.5812/aapm.35900
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author Yazdani, Javad
Aghamohamadi, Davood
Amani, Masoomeh
Mesgarzadeh, Ali Hossein
Maghbooli Asl, Davood
Pourlak, Tannaz
author_facet Yazdani, Javad
Aghamohamadi, Davood
Amani, Masoomeh
Mesgarzadeh, Ali Hossein
Maghbooli Asl, Davood
Pourlak, Tannaz
author_sort Yazdani, Javad
collection PubMed
description BACKGROUND: Postoperative pain from open reduction and internal fixation of mandibular fracture is a serious issue. Amantadine is an N-methyl-D-aspartic acid or N-methyl-D-aspartate (NMDA) receptor antagonist that can be effective against postoperative pain. OBJECTIVES: The present study examined the efficacy of amantadine in alleviating the postoperative pain of mandibular fracture surgery. PATIENTS AND METHODS: In this double-blind study, 60 patients (ASA physical status I–II) were randomly divided into two groups. The mean ages of the participants were 31.2 ± 13.1 years and 32.3 ± 18.1 years, respectively. The male/female ratios were 24/6 and 26/4, respectively, in the case and control groups. Randomization was based on a single sequence of random assignments using computer-generated random numbers. Group I was given oral amantadine 100 mg 1 hour before surgery, and group II received a placebo at the identical time. Through PCA pumps, patients received a bolus dose of morphine at 0.02 mg/kg body weight, to a maximum of 1.5 mg. PCA pumps were set at 6 minutes lockout intervals and a maximum dose of 0.15 mg/kg/h, to a maximum of 10 mg/h. Pain was assessed using a visual analog scale (VAS) at 0, 2, 4, 6, 12, and 24 hours and 1, 2, 3, 4, 5, and 6 months after surgery. The amounts of analgesic consumed were recorded for the first 24 hours, and for 6 months after surgery. RESULTS: There were no significant differences between the two groups with respect to age, gender, nausea and vomiting, sleep quality, blood pressure, and heart rate. No significant differences were observed between the two groups in pain scores (P = 0.39) and analgesic consumption (P = 0.78). CONCLUSIONS: The results suggest that a single dose of preoperative oral amantadine did not reduce acute or chronic postoperative pain, nor analgesic consumption.
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spelling pubmed-50181582016-09-16 Effect of Preoperative Oral Amantadine on Acute and Chronic Postoperative Pain After Mandibular Fracture Surgery Yazdani, Javad Aghamohamadi, Davood Amani, Masoomeh Mesgarzadeh, Ali Hossein Maghbooli Asl, Davood Pourlak, Tannaz Anesth Pain Med Research Article BACKGROUND: Postoperative pain from open reduction and internal fixation of mandibular fracture is a serious issue. Amantadine is an N-methyl-D-aspartic acid or N-methyl-D-aspartate (NMDA) receptor antagonist that can be effective against postoperative pain. OBJECTIVES: The present study examined the efficacy of amantadine in alleviating the postoperative pain of mandibular fracture surgery. PATIENTS AND METHODS: In this double-blind study, 60 patients (ASA physical status I–II) were randomly divided into two groups. The mean ages of the participants were 31.2 ± 13.1 years and 32.3 ± 18.1 years, respectively. The male/female ratios were 24/6 and 26/4, respectively, in the case and control groups. Randomization was based on a single sequence of random assignments using computer-generated random numbers. Group I was given oral amantadine 100 mg 1 hour before surgery, and group II received a placebo at the identical time. Through PCA pumps, patients received a bolus dose of morphine at 0.02 mg/kg body weight, to a maximum of 1.5 mg. PCA pumps were set at 6 minutes lockout intervals and a maximum dose of 0.15 mg/kg/h, to a maximum of 10 mg/h. Pain was assessed using a visual analog scale (VAS) at 0, 2, 4, 6, 12, and 24 hours and 1, 2, 3, 4, 5, and 6 months after surgery. The amounts of analgesic consumed were recorded for the first 24 hours, and for 6 months after surgery. RESULTS: There were no significant differences between the two groups with respect to age, gender, nausea and vomiting, sleep quality, blood pressure, and heart rate. No significant differences were observed between the two groups in pain scores (P = 0.39) and analgesic consumption (P = 0.78). CONCLUSIONS: The results suggest that a single dose of preoperative oral amantadine did not reduce acute or chronic postoperative pain, nor analgesic consumption. Kowsar 2016-05-09 /pmc/articles/PMC5018158/ /pubmed/27642581 http://dx.doi.org/10.5812/aapm.35900 Text en Copyright © 2016, Iranian Society of Regional Anesthesia and Pain Medicine (ISRAPM) http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Research Article
Yazdani, Javad
Aghamohamadi, Davood
Amani, Masoomeh
Mesgarzadeh, Ali Hossein
Maghbooli Asl, Davood
Pourlak, Tannaz
Effect of Preoperative Oral Amantadine on Acute and Chronic Postoperative Pain After Mandibular Fracture Surgery
title Effect of Preoperative Oral Amantadine on Acute and Chronic Postoperative Pain After Mandibular Fracture Surgery
title_full Effect of Preoperative Oral Amantadine on Acute and Chronic Postoperative Pain After Mandibular Fracture Surgery
title_fullStr Effect of Preoperative Oral Amantadine on Acute and Chronic Postoperative Pain After Mandibular Fracture Surgery
title_full_unstemmed Effect of Preoperative Oral Amantadine on Acute and Chronic Postoperative Pain After Mandibular Fracture Surgery
title_short Effect of Preoperative Oral Amantadine on Acute and Chronic Postoperative Pain After Mandibular Fracture Surgery
title_sort effect of preoperative oral amantadine on acute and chronic postoperative pain after mandibular fracture surgery
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018158/
https://www.ncbi.nlm.nih.gov/pubmed/27642581
http://dx.doi.org/10.5812/aapm.35900
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