MIA: non-targeted mass isotopolome analysis

Summary: MIA detects and visualizes isotopic enrichment in gas chromatography electron ionization mass spectrometry (GC–EI-MS) datasets in a non-targeted manner. It provides an easy-to-use graphical user interface that allows for visual mass isotopomer distribution analysis across multiple datasets....

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Detalles Bibliográficos
Autores principales: Weindl, Daniel, Wegner, Andre, Hiller, Karsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Applications Notes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018370/
https://www.ncbi.nlm.nih.gov/pubmed/27273671
http://dx.doi.org/10.1093/bioinformatics/btw317
Descripción
Sumario:Summary: MIA detects and visualizes isotopic enrichment in gas chromatography electron ionization mass spectrometry (GC–EI-MS) datasets in a non-targeted manner. It provides an easy-to-use graphical user interface that allows for visual mass isotopomer distribution analysis across multiple datasets. MIA helps to reveal changes in metabolic fluxes, visualizes metabolic proximity of isotopically enriched compounds and shows the fate of the applied stable isotope labeled tracer. Availability and Implementation: Linux and Windows binaries, documentation, and sample data are freely available for download at http://massisotopolomeanalyzer.lu. MIA is a stand-alone application implemented in C ++  and based on Qt5, NTFD and the MetaboliteDetector framework. Contact: karsten.hiller@uni.lu

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