Macropinocytosis Exploitation by Cancers and Cancer Therapeutics

Macropinocytosis has long been known as a primary method for cellular intake of fluid-phase and membrane-bound bulk cargo. This review seeks to re-examine the latest studies to emphasize how cancers exploit macropinocytosis to further their tumorigenesis, including details in how macropinocytosis ca...

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Detalles Bibliográficos
Autores principales: Ha, Kevin D., Bidlingmaier, Scott M., Liu, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018483/
https://www.ncbi.nlm.nih.gov/pubmed/27672367
http://dx.doi.org/10.3389/fphys.2016.00381
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author Ha, Kevin D.
Bidlingmaier, Scott M.
Liu, Bin
author_facet Ha, Kevin D.
Bidlingmaier, Scott M.
Liu, Bin
author_sort Ha, Kevin D.
collection PubMed
description Macropinocytosis has long been known as a primary method for cellular intake of fluid-phase and membrane-bound bulk cargo. This review seeks to re-examine the latest studies to emphasize how cancers exploit macropinocytosis to further their tumorigenesis, including details in how macropinocytosis can be adapted to serve diverse functions. Furthermore, this review will also cover the latest endeavors in targeting macropinocytosis as an avenue for novel therapeutics.
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spelling pubmed-50184832016-09-26 Macropinocytosis Exploitation by Cancers and Cancer Therapeutics Ha, Kevin D. Bidlingmaier, Scott M. Liu, Bin Front Physiol Physiology Macropinocytosis has long been known as a primary method for cellular intake of fluid-phase and membrane-bound bulk cargo. This review seeks to re-examine the latest studies to emphasize how cancers exploit macropinocytosis to further their tumorigenesis, including details in how macropinocytosis can be adapted to serve diverse functions. Furthermore, this review will also cover the latest endeavors in targeting macropinocytosis as an avenue for novel therapeutics. Frontiers Media S.A. 2016-09-12 /pmc/articles/PMC5018483/ /pubmed/27672367 http://dx.doi.org/10.3389/fphys.2016.00381 Text en Copyright © 2016 Ha, Bidlingmaier and Liu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Ha, Kevin D.
Bidlingmaier, Scott M.
Liu, Bin
Macropinocytosis Exploitation by Cancers and Cancer Therapeutics
title Macropinocytosis Exploitation by Cancers and Cancer Therapeutics
title_full Macropinocytosis Exploitation by Cancers and Cancer Therapeutics
title_fullStr Macropinocytosis Exploitation by Cancers and Cancer Therapeutics
title_full_unstemmed Macropinocytosis Exploitation by Cancers and Cancer Therapeutics
title_short Macropinocytosis Exploitation by Cancers and Cancer Therapeutics
title_sort macropinocytosis exploitation by cancers and cancer therapeutics
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018483/
https://www.ncbi.nlm.nih.gov/pubmed/27672367
http://dx.doi.org/10.3389/fphys.2016.00381
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