Proteolytic inactivation of nuclear alarmin high-mobility group box 1 by complement protease C1s during apoptosis

Effective clearance of apoptotic cells by phagocytes prevents the release of intracellular alarmins and manifestation of autoimmunity. This prompt efferocytosis is complemented by intracellular proteolytic degradation that occurs within the apoptotic cells and in the efferosome of the phagocytes. Al...

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Detalles Bibliográficos
Autores principales: Yeo, J G, Leong, J, Arkachaisri, T, Cai, Y, Teo, B H D, Tan, J H T, Das, L, Lu, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018544/
https://www.ncbi.nlm.nih.gov/pubmed/27648302
http://dx.doi.org/10.1038/cddiscovery.2016.69

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