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Astaxanthin affects oxidative stress and hyposalivation in aging mice
Oral dryness, a serious problem for the aging Japanese society, is induced by aging-related hyposalivation and causes dysphagia, dysgeusia, inadaptation of dentures, and growth of oral Candida albicans. Oxidative stress clearly plays a role in decreasing saliva secretion and treatment with antioxida...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
the Society for Free Radical Research Japan
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018570/ https://www.ncbi.nlm.nih.gov/pubmed/27698533 http://dx.doi.org/10.3164/jcbn.15-150 |
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author | Kuraji, Manatsu Matsuno, Tomonori Satoh, Tazuko |
author_facet | Kuraji, Manatsu Matsuno, Tomonori Satoh, Tazuko |
author_sort | Kuraji, Manatsu |
collection | PubMed |
description | Oral dryness, a serious problem for the aging Japanese society, is induced by aging-related hyposalivation and causes dysphagia, dysgeusia, inadaptation of dentures, and growth of oral Candida albicans. Oxidative stress clearly plays a role in decreasing saliva secretion and treatment with antioxidants such astaxanthin supplements may be beneficial. Therefore, we evaluated the effects of astaxanthin on the oral saliva secretory function of aging mice. The saliva flow increased in astaxanthin-treated mice 72 weeks after administration while that of the control decreased by half. The plasma d-ROMs values of the control but not astaxanthin-treated group measured before and 72 weeks after treatment increased. The diacron-reactive oxygen metabolites (d-ROMs) value of astaxanthin-treated mice 72 weeks after treatment was significantly lower than that of the control group was. The plasma biological antioxidative potential (BAP) values of the control but not astaxanthin-treated mice before and 72 weeks after treatment decreased. Moreover, the BAP value of the astaxanthin-treated group 72 weeks after treatment was significantly higher than that of the control was. Furthermore, the submandibular glands of astaxanthin-treated mice had fewer inflammatory cells than the control did. Specifically, immunofluorescence revealed a significantly large aquaporin-5 positive cells in astaxanthin-treated mice. Our results suggest that astaxanthin treatment may prevent age-related decreased saliva secretion. |
format | Online Article Text |
id | pubmed-5018570 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | the Society for Free Radical Research Japan |
record_format | MEDLINE/PubMed |
spelling | pubmed-50185702016-10-03 Astaxanthin affects oxidative stress and hyposalivation in aging mice Kuraji, Manatsu Matsuno, Tomonori Satoh, Tazuko J Clin Biochem Nutr Original Article Oral dryness, a serious problem for the aging Japanese society, is induced by aging-related hyposalivation and causes dysphagia, dysgeusia, inadaptation of dentures, and growth of oral Candida albicans. Oxidative stress clearly plays a role in decreasing saliva secretion and treatment with antioxidants such astaxanthin supplements may be beneficial. Therefore, we evaluated the effects of astaxanthin on the oral saliva secretory function of aging mice. The saliva flow increased in astaxanthin-treated mice 72 weeks after administration while that of the control decreased by half. The plasma d-ROMs values of the control but not astaxanthin-treated group measured before and 72 weeks after treatment increased. The diacron-reactive oxygen metabolites (d-ROMs) value of astaxanthin-treated mice 72 weeks after treatment was significantly lower than that of the control group was. The plasma biological antioxidative potential (BAP) values of the control but not astaxanthin-treated mice before and 72 weeks after treatment decreased. Moreover, the BAP value of the astaxanthin-treated group 72 weeks after treatment was significantly higher than that of the control was. Furthermore, the submandibular glands of astaxanthin-treated mice had fewer inflammatory cells than the control did. Specifically, immunofluorescence revealed a significantly large aquaporin-5 positive cells in astaxanthin-treated mice. Our results suggest that astaxanthin treatment may prevent age-related decreased saliva secretion. the Society for Free Radical Research Japan 2016-09 2016-07-16 /pmc/articles/PMC5018570/ /pubmed/27698533 http://dx.doi.org/10.3164/jcbn.15-150 Text en Copyright © 2016 JCBN This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kuraji, Manatsu Matsuno, Tomonori Satoh, Tazuko Astaxanthin affects oxidative stress and hyposalivation in aging mice |
title | Astaxanthin affects oxidative stress and hyposalivation in aging mice |
title_full | Astaxanthin affects oxidative stress and hyposalivation in aging mice |
title_fullStr | Astaxanthin affects oxidative stress and hyposalivation in aging mice |
title_full_unstemmed | Astaxanthin affects oxidative stress and hyposalivation in aging mice |
title_short | Astaxanthin affects oxidative stress and hyposalivation in aging mice |
title_sort | astaxanthin affects oxidative stress and hyposalivation in aging mice |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018570/ https://www.ncbi.nlm.nih.gov/pubmed/27698533 http://dx.doi.org/10.3164/jcbn.15-150 |
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