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The spectrum of congenital heart diseases in down syndrome: A retrospective study from Northwest Saudi Arabia
OBJECTIVES: To to define the frequency and patterns of congenital heart disease (CHD) among children with Down syndrome (DS) in Northwest Saudi Arabia. METHODS: We included children with confirmed DS referred to the regional pediatric cardiology unit in Madinah Maternity and Children Hospital betwee...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Saudi Medical Journal
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018641/ https://www.ncbi.nlm.nih.gov/pubmed/27381537 http://dx.doi.org/10.15537/smj.2016.7.14536 |
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author | Morsy, Mohamed M. Algrigri, Osama O. Salem, Sherif S. Abosedera, Mostafa M. Abutaleb, Ashraf R. Al-Harbi, Khaled M. Al-Mozainy, Ibrahim S. Alnajjar, Abdulhameed A. Habeb, Abdelhadi M. Abo-Haded, Hany M. |
author_facet | Morsy, Mohamed M. Algrigri, Osama O. Salem, Sherif S. Abosedera, Mostafa M. Abutaleb, Ashraf R. Al-Harbi, Khaled M. Al-Mozainy, Ibrahim S. Alnajjar, Abdulhameed A. Habeb, Abdelhadi M. Abo-Haded, Hany M. |
author_sort | Morsy, Mohamed M. |
collection | PubMed |
description | OBJECTIVES: To to define the frequency and patterns of congenital heart disease (CHD) among children with Down syndrome (DS) in Northwest Saudi Arabia. METHODS: We included children with confirmed DS referred to the regional pediatric cardiology unit in Madinah Maternity and Children Hospital between January 2008 and December 2013. Children were identified from the unit’s data-base and the charts were reviewed retrospectively. We excluded term and preterm children with patent ducts arteriosus (PDA) and persistent foramen oval spontaneously resolved during the first 4 weeks of life. RESULTS: A total of 302 children with DS were identified (50.3% male). Of these, 177 (58.6%) had CHD. Atrioventricular septal defect (AVSD) was the most frequent lesion identified in 72/177 (40.7%) followed by mixed left to right shunt defects (14.7%) and secundum atrial septal defect (ASD) (11.8%). Ventricular septal defect was detected in 10.7% and 8.5% had PDA beyond the neonatal period. There was no gender difference in the frequency of CHD (p=0.9) and the presence of CHD was not related to the genetic cause of DS (p=0.9). CONCLUSION: The frequency of CHD in our DS cohort is comparable with Europe, Asia, and other KSA regions. However its pattern appears to be different from some areas in KSA. |
format | Online Article Text |
id | pubmed-5018641 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Saudi Medical Journal |
record_format | MEDLINE/PubMed |
spelling | pubmed-50186412016-09-19 The spectrum of congenital heart diseases in down syndrome: A retrospective study from Northwest Saudi Arabia Morsy, Mohamed M. Algrigri, Osama O. Salem, Sherif S. Abosedera, Mostafa M. Abutaleb, Ashraf R. Al-Harbi, Khaled M. Al-Mozainy, Ibrahim S. Alnajjar, Abdulhameed A. Habeb, Abdelhadi M. Abo-Haded, Hany M. Saudi Med J Original Article OBJECTIVES: To to define the frequency and patterns of congenital heart disease (CHD) among children with Down syndrome (DS) in Northwest Saudi Arabia. METHODS: We included children with confirmed DS referred to the regional pediatric cardiology unit in Madinah Maternity and Children Hospital between January 2008 and December 2013. Children were identified from the unit’s data-base and the charts were reviewed retrospectively. We excluded term and preterm children with patent ducts arteriosus (PDA) and persistent foramen oval spontaneously resolved during the first 4 weeks of life. RESULTS: A total of 302 children with DS were identified (50.3% male). Of these, 177 (58.6%) had CHD. Atrioventricular septal defect (AVSD) was the most frequent lesion identified in 72/177 (40.7%) followed by mixed left to right shunt defects (14.7%) and secundum atrial septal defect (ASD) (11.8%). Ventricular septal defect was detected in 10.7% and 8.5% had PDA beyond the neonatal period. There was no gender difference in the frequency of CHD (p=0.9) and the presence of CHD was not related to the genetic cause of DS (p=0.9). CONCLUSION: The frequency of CHD in our DS cohort is comparable with Europe, Asia, and other KSA regions. However its pattern appears to be different from some areas in KSA. Saudi Medical Journal 2016-07 /pmc/articles/PMC5018641/ /pubmed/27381537 http://dx.doi.org/10.15537/smj.2016.7.14536 Text en Copyright: © Saudi Medical Journal http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Morsy, Mohamed M. Algrigri, Osama O. Salem, Sherif S. Abosedera, Mostafa M. Abutaleb, Ashraf R. Al-Harbi, Khaled M. Al-Mozainy, Ibrahim S. Alnajjar, Abdulhameed A. Habeb, Abdelhadi M. Abo-Haded, Hany M. The spectrum of congenital heart diseases in down syndrome: A retrospective study from Northwest Saudi Arabia |
title | The spectrum of congenital heart diseases in down syndrome: A retrospective study from Northwest Saudi Arabia |
title_full | The spectrum of congenital heart diseases in down syndrome: A retrospective study from Northwest Saudi Arabia |
title_fullStr | The spectrum of congenital heart diseases in down syndrome: A retrospective study from Northwest Saudi Arabia |
title_full_unstemmed | The spectrum of congenital heart diseases in down syndrome: A retrospective study from Northwest Saudi Arabia |
title_short | The spectrum of congenital heart diseases in down syndrome: A retrospective study from Northwest Saudi Arabia |
title_sort | spectrum of congenital heart diseases in down syndrome: a retrospective study from northwest saudi arabia |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018641/ https://www.ncbi.nlm.nih.gov/pubmed/27381537 http://dx.doi.org/10.15537/smj.2016.7.14536 |
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