Novel O-GlcNAcylation on Ser(40) of canonical H2A isoforms specific to viviparity

We report here newly discovered O-linked-N-acetylglucosamine (O-GlcNAc) modification of histone H2A at Ser(40) (H2AS40Gc). The mouse genome contains 18 H2A isoforms, of which 13 have Ser(40) and the other five have Ala(40). The combination of production of monoclonal antibody and mass spectrometric...

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Detalles Bibliográficos
Autores principales: Hirosawa, Mitsuko, Hayakawa, Koji, Yoneda, Chikako, Arai, Daisuke, Shiota, Hitoshi, Suzuki, Takehiro, Tanaka, Satoshi, Dohmae, Naoshi, Shiota, Kunio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018834/
https://www.ncbi.nlm.nih.gov/pubmed/27615797
http://dx.doi.org/10.1038/srep31785

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