WEE1 inhibition in pancreatic cancer cells is dependent on DNA repair status in a context dependent manner

Pancreatic ductal adenocarcinoma (PDA) is a lethal disease, in part, because of the lack of effective targeted therapeutic options. MK-1775 (also known as AZD1775), a mitotic inhibitor, has been demonstrated to enhance the anti-tumor effects of DNA damaging agents such as gemcitabine. We evaluated t...

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Detalles Bibliográficos
Autores principales: Lal, Shruti, Zarei, Mahsa, Chand, Saswati N., Dylgjeri, Emanuela, Mambelli-Lisboa, Nicole C., Pishvaian, Michael J., Yeo, Charles J., Winter, Jordan M., Brody, Jonathan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018859/
https://www.ncbi.nlm.nih.gov/pubmed/27616351
http://dx.doi.org/10.1038/srep33323

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018859/
https://www.ncbi.nlm.nih.gov/pubmed/27616351
http://dx.doi.org/10.1038/srep33323

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