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Role of Haptoglobin in Health and Disease: A Focus on Diabetes
In Brief Prospective identification of individuals with diabetes who are at greatest risk for developing complications would have considerable public health importance by allowing appropriate resources to be focused on those who would benefit most from aggressive intervention. Haptoglobin (Hp) is an...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019011/ https://www.ncbi.nlm.nih.gov/pubmed/27621532 http://dx.doi.org/10.2337/diaclin.34.3.148 |
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author | MacKellar, Mark Vigerust, David J. |
author_facet | MacKellar, Mark Vigerust, David J. |
author_sort | MacKellar, Mark |
collection | PubMed |
description | In Brief Prospective identification of individuals with diabetes who are at greatest risk for developing complications would have considerable public health importance by allowing appropriate resources to be focused on those who would benefit most from aggressive intervention. Haptoglobin (Hp) is an acute-phase protein that is crucial for the elimination of free hemoglobin and the neutralization of oxidative damage. In the past two decades, associations have been made between polymorphisms in Hp and complications arising from diabetes. Individuals with polymorphism in Hp have been shown to have significantly higher risk of developing cardiovascular disease. This review summarizes the current literature on the role of Hp in health and disease, with a focus on diabetes. |
format | Online Article Text |
id | pubmed-5019011 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-50190112017-07-01 Role of Haptoglobin in Health and Disease: A Focus on Diabetes MacKellar, Mark Vigerust, David J. Clin Diabetes Feature Articles In Brief Prospective identification of individuals with diabetes who are at greatest risk for developing complications would have considerable public health importance by allowing appropriate resources to be focused on those who would benefit most from aggressive intervention. Haptoglobin (Hp) is an acute-phase protein that is crucial for the elimination of free hemoglobin and the neutralization of oxidative damage. In the past two decades, associations have been made between polymorphisms in Hp and complications arising from diabetes. Individuals with polymorphism in Hp have been shown to have significantly higher risk of developing cardiovascular disease. This review summarizes the current literature on the role of Hp in health and disease, with a focus on diabetes. American Diabetes Association 2016-07 /pmc/articles/PMC5019011/ /pubmed/27621532 http://dx.doi.org/10.2337/diaclin.34.3.148 Text en © 2016 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0 for details. |
spellingShingle | Feature Articles MacKellar, Mark Vigerust, David J. Role of Haptoglobin in Health and Disease: A Focus on Diabetes |
title | Role of Haptoglobin in Health and Disease: A Focus on Diabetes |
title_full | Role of Haptoglobin in Health and Disease: A Focus on Diabetes |
title_fullStr | Role of Haptoglobin in Health and Disease: A Focus on Diabetes |
title_full_unstemmed | Role of Haptoglobin in Health and Disease: A Focus on Diabetes |
title_short | Role of Haptoglobin in Health and Disease: A Focus on Diabetes |
title_sort | role of haptoglobin in health and disease: a focus on diabetes |
topic | Feature Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019011/ https://www.ncbi.nlm.nih.gov/pubmed/27621532 http://dx.doi.org/10.2337/diaclin.34.3.148 |
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