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Validation of the Vitiligo Noticeability Scale: a patient‐reported outcome measure of vitiligo treatment success
BACKGROUND: Patient‐reported outcome measures are rarely used in vitiligo trials. The Vitiligo Noticeability Scale (VNS) is a new patient‐reported outcome measure assessing how ‘noticeable’ vitiligo patches are after treatment. The noticeability of vitiligo after treatment is an important indicator...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019146/ https://www.ncbi.nlm.nih.gov/pubmed/26409256 http://dx.doi.org/10.1111/bjd.14208 |
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author | Batchelor, J.M. Tan, W. Tour, S. Yong, A. Montgomery, A.A. Thomas, K.S. |
author_facet | Batchelor, J.M. Tan, W. Tour, S. Yong, A. Montgomery, A.A. Thomas, K.S. |
author_sort | Batchelor, J.M. |
collection | PubMed |
description | BACKGROUND: Patient‐reported outcome measures are rarely used in vitiligo trials. The Vitiligo Noticeability Scale (VNS) is a new patient‐reported outcome measure assessing how ‘noticeable’ vitiligo patches are after treatment. The noticeability of vitiligo after treatment is an important indicator of treatment success from the patient's perspective. OBJECTIVES: To evaluate the construct validity, acceptability and interpretability of the VNS. METHODS: Clinicians (n = 33) and patients with vitiligo (n = 101) examined 39 image pairs, each depicting a vitiligo lesion pre‐ and post‐treatment. Using an online questionnaire, respondents gave a global assessment of treatment success and a VNS score for treatment response. Clinicians also estimated percentage repigmentation of lesions (< 25%; 25–50%; 51–75%; > 75%). Treatment success was defined as ‘yes’ on global assessment, a VNS score of 4 or 5, and > 75% repigmentation. Agreement between respondents and the different scales was assessed using kappa (κ) statistics. RESULTS: Vitiligo Noticeability Scale scores were associated with both patient‐ and clinician‐reported global treatment success (κ = 0·54 and κ = 0·47, respectively). Percentage repigmentation showed a weaker association with patient‐ and clinician‐reported global treatment success (κ = 0·39 and κ = 0·29, respectively). VNS scores of 4 or 5 can be interpreted as representing treatment success. Images depicting post‐treatment hyperpigmentation were less likely to be rated as successful. CONCLUSIONS: The VNS is a valid patient‐reported measure of vitiligo treatment success. Further validation of the VNS is required, using larger sets of clinical pre‐ and post‐treatment images, affecting a wider range of anatomical sites. |
format | Online Article Text |
id | pubmed-5019146 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-50191462016-09-23 Validation of the Vitiligo Noticeability Scale: a patient‐reported outcome measure of vitiligo treatment success Batchelor, J.M. Tan, W. Tour, S. Yong, A. Montgomery, A.A. Thomas, K.S. Br J Dermatol Original Articles BACKGROUND: Patient‐reported outcome measures are rarely used in vitiligo trials. The Vitiligo Noticeability Scale (VNS) is a new patient‐reported outcome measure assessing how ‘noticeable’ vitiligo patches are after treatment. The noticeability of vitiligo after treatment is an important indicator of treatment success from the patient's perspective. OBJECTIVES: To evaluate the construct validity, acceptability and interpretability of the VNS. METHODS: Clinicians (n = 33) and patients with vitiligo (n = 101) examined 39 image pairs, each depicting a vitiligo lesion pre‐ and post‐treatment. Using an online questionnaire, respondents gave a global assessment of treatment success and a VNS score for treatment response. Clinicians also estimated percentage repigmentation of lesions (< 25%; 25–50%; 51–75%; > 75%). Treatment success was defined as ‘yes’ on global assessment, a VNS score of 4 or 5, and > 75% repigmentation. Agreement between respondents and the different scales was assessed using kappa (κ) statistics. RESULTS: Vitiligo Noticeability Scale scores were associated with both patient‐ and clinician‐reported global treatment success (κ = 0·54 and κ = 0·47, respectively). Percentage repigmentation showed a weaker association with patient‐ and clinician‐reported global treatment success (κ = 0·39 and κ = 0·29, respectively). VNS scores of 4 or 5 can be interpreted as representing treatment success. Images depicting post‐treatment hyperpigmentation were less likely to be rated as successful. CONCLUSIONS: The VNS is a valid patient‐reported measure of vitiligo treatment success. Further validation of the VNS is required, using larger sets of clinical pre‐ and post‐treatment images, affecting a wider range of anatomical sites. John Wiley and Sons Inc. 2016-02 2015-12-14 /pmc/articles/PMC5019146/ /pubmed/26409256 http://dx.doi.org/10.1111/bjd.14208 Text en © 2015 The Authors. British Journal of Dermatology published by John Wiley & Sons Ltd on behalf of British Association of Dermatologists. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Articles Batchelor, J.M. Tan, W. Tour, S. Yong, A. Montgomery, A.A. Thomas, K.S. Validation of the Vitiligo Noticeability Scale: a patient‐reported outcome measure of vitiligo treatment success |
title | Validation of the Vitiligo Noticeability Scale: a patient‐reported outcome measure of vitiligo treatment success
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title_full | Validation of the Vitiligo Noticeability Scale: a patient‐reported outcome measure of vitiligo treatment success
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title_fullStr | Validation of the Vitiligo Noticeability Scale: a patient‐reported outcome measure of vitiligo treatment success
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title_full_unstemmed | Validation of the Vitiligo Noticeability Scale: a patient‐reported outcome measure of vitiligo treatment success
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title_short | Validation of the Vitiligo Noticeability Scale: a patient‐reported outcome measure of vitiligo treatment success
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title_sort | validation of the vitiligo noticeability scale: a patient‐reported outcome measure of vitiligo treatment success |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019146/ https://www.ncbi.nlm.nih.gov/pubmed/26409256 http://dx.doi.org/10.1111/bjd.14208 |
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