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Association of CAT C-262T and SOD1 A251G single nucleotide polymorphisms susceptible to gastric cancer

Oxidative stress is known to be one of the major factors involved in the development and progression of cancer. Oxidative stress can occur due to an imbalance between concentrations of reactive oxygen species and antioxidant capacities. Catalase (CAT; OMIM 115500) and superoxide dismutase 1 (SOD1; O...

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Autores principales: Ebrahimpour, Shiva, Saadat, Iraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shiraz University 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019308/
https://www.ncbi.nlm.nih.gov/pubmed/27843986
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author Ebrahimpour, Shiva
Saadat, Iraj
author_facet Ebrahimpour, Shiva
Saadat, Iraj
author_sort Ebrahimpour, Shiva
collection PubMed
description Oxidative stress is known to be one of the major factors involved in the development and progression of cancer. Oxidative stress can occur due to an imbalance between concentrations of reactive oxygen species and antioxidant capacities. Catalase (CAT; OMIM 115500) and superoxide dismutase 1 (SOD1; OMIM 147450) play important roles in the primary defense against oxidative stress. In the present study, we investigated possible associations between polymorphisms of CAT C-262T (rs1001179) and SOD1 A251G (rs2070424) with susceptibility to gastric cancer. This case-control study included 160 gastric cancer patients and 241 age and gender frequency-matched healthy controls. Genotyping was done using PCR-RFLP based method. There were no significant differences in T allele frequencies in patients as compared to the controls in the CAT C-262T polymorphism (OR=0.80, 95% CI: 0.52- 1.23, P=0.304). Subjects with AG (OR=0.47, 95% CI: 0.24-0.91, P=0.026) or AG+GG (OR=0.45, 95% CI: 0.23-0.88, P=0.021) genotypes of the rs2070424 polymorphism were at lower risks of developing gastric cancer in comparison with the AA genotype. Our findings showed that there was no significant association between CAT C-262T polymorphism and gastric cancer susceptibility. However, we found that the G allele of the SOD1 A251G polymorphism has protective effects against the risk of gastric cancer.
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spelling pubmed-50193082016-11-14 Association of CAT C-262T and SOD1 A251G single nucleotide polymorphisms susceptible to gastric cancer Ebrahimpour, Shiva Saadat, Iraj Mol Biol Res Commun Original Article Oxidative stress is known to be one of the major factors involved in the development and progression of cancer. Oxidative stress can occur due to an imbalance between concentrations of reactive oxygen species and antioxidant capacities. Catalase (CAT; OMIM 115500) and superoxide dismutase 1 (SOD1; OMIM 147450) play important roles in the primary defense against oxidative stress. In the present study, we investigated possible associations between polymorphisms of CAT C-262T (rs1001179) and SOD1 A251G (rs2070424) with susceptibility to gastric cancer. This case-control study included 160 gastric cancer patients and 241 age and gender frequency-matched healthy controls. Genotyping was done using PCR-RFLP based method. There were no significant differences in T allele frequencies in patients as compared to the controls in the CAT C-262T polymorphism (OR=0.80, 95% CI: 0.52- 1.23, P=0.304). Subjects with AG (OR=0.47, 95% CI: 0.24-0.91, P=0.026) or AG+GG (OR=0.45, 95% CI: 0.23-0.88, P=0.021) genotypes of the rs2070424 polymorphism were at lower risks of developing gastric cancer in comparison with the AA genotype. Our findings showed that there was no significant association between CAT C-262T polymorphism and gastric cancer susceptibility. However, we found that the G allele of the SOD1 A251G polymorphism has protective effects against the risk of gastric cancer. Shiraz University 2014-12 /pmc/articles/PMC5019308/ /pubmed/27843986 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ebrahimpour, Shiva
Saadat, Iraj
Association of CAT C-262T and SOD1 A251G single nucleotide polymorphisms susceptible to gastric cancer
title Association of CAT C-262T and SOD1 A251G single nucleotide polymorphisms susceptible to gastric cancer
title_full Association of CAT C-262T and SOD1 A251G single nucleotide polymorphisms susceptible to gastric cancer
title_fullStr Association of CAT C-262T and SOD1 A251G single nucleotide polymorphisms susceptible to gastric cancer
title_full_unstemmed Association of CAT C-262T and SOD1 A251G single nucleotide polymorphisms susceptible to gastric cancer
title_short Association of CAT C-262T and SOD1 A251G single nucleotide polymorphisms susceptible to gastric cancer
title_sort association of cat c-262t and sod1 a251g single nucleotide polymorphisms susceptible to gastric cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019308/
https://www.ncbi.nlm.nih.gov/pubmed/27843986
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