Analysis of IL-33 gene polymorphism (rs11792633 C/T) and risk of schizophrenia

Recently, inflammation has been found to be a significant factor in the development of Schizophrenia (SCZ). The aim of the present research was to investigate whether interleukin-33 (IL-33, OMIM: 608678) gene polymorphism (rs11792633, C/T) is associated with the development of SCZ or not. DNA was is...

Descripción completa

Detalles Bibliográficos
Autores principales: Kordi-Tamandani, Dor Mohammad, Bahrami, Ahmad Reza, Sabbaghi-Ghale-no, Raziye, Soleimani, Hanieh, Baranzehi, Tayebe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shiraz University 2016
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019332/
https://www.ncbi.nlm.nih.gov/pubmed/27844019
_version_ 1782453039105310720
author Kordi-Tamandani, Dor Mohammad
Bahrami, Ahmad Reza
Sabbaghi-Ghale-no, Raziye
Soleimani, Hanieh
Baranzehi, Tayebe
author_facet Kordi-Tamandani, Dor Mohammad
Bahrami, Ahmad Reza
Sabbaghi-Ghale-no, Raziye
Soleimani, Hanieh
Baranzehi, Tayebe
author_sort Kordi-Tamandani, Dor Mohammad
collection PubMed
description Recently, inflammation has been found to be a significant factor in the development of Schizophrenia (SCZ). The aim of the present research was to investigate whether interleukin-33 (IL-33, OMIM: 608678) gene polymorphism (rs11792633, C/T) is associated with the development of SCZ or not. DNA was isolated from the serum of 70 patients with SCZ and 70 healthy controls. The PCR based method was used for detection of the IL-33 polymorphism. The CT (OR=0.05, 95% CI: 0.003-0.057, P<0.001) and TT (OR=0.12, 95% CI: 0.028-0.46, P<0.001) genotypes significantly decreased the risk of SCZ. Our present findings indicate that the IL-33 polymorphism associated with the risk of SCZ.
format Online
Article
Text
id pubmed-5019332
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Shiraz University
record_format MEDLINE/PubMed
spelling pubmed-50193322016-11-14 Analysis of IL-33 gene polymorphism (rs11792633 C/T) and risk of schizophrenia Kordi-Tamandani, Dor Mohammad Bahrami, Ahmad Reza Sabbaghi-Ghale-no, Raziye Soleimani, Hanieh Baranzehi, Tayebe Mol Biol Res Commun Short Communication Recently, inflammation has been found to be a significant factor in the development of Schizophrenia (SCZ). The aim of the present research was to investigate whether interleukin-33 (IL-33, OMIM: 608678) gene polymorphism (rs11792633, C/T) is associated with the development of SCZ or not. DNA was isolated from the serum of 70 patients with SCZ and 70 healthy controls. The PCR based method was used for detection of the IL-33 polymorphism. The CT (OR=0.05, 95% CI: 0.003-0.057, P<0.001) and TT (OR=0.12, 95% CI: 0.028-0.46, P<0.001) genotypes significantly decreased the risk of SCZ. Our present findings indicate that the IL-33 polymorphism associated with the risk of SCZ. Shiraz University 2016-03 /pmc/articles/PMC5019332/ /pubmed/27844019 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Kordi-Tamandani, Dor Mohammad
Bahrami, Ahmad Reza
Sabbaghi-Ghale-no, Raziye
Soleimani, Hanieh
Baranzehi, Tayebe
Analysis of IL-33 gene polymorphism (rs11792633 C/T) and risk of schizophrenia
title Analysis of IL-33 gene polymorphism (rs11792633 C/T) and risk of schizophrenia
title_full Analysis of IL-33 gene polymorphism (rs11792633 C/T) and risk of schizophrenia
title_fullStr Analysis of IL-33 gene polymorphism (rs11792633 C/T) and risk of schizophrenia
title_full_unstemmed Analysis of IL-33 gene polymorphism (rs11792633 C/T) and risk of schizophrenia
title_short Analysis of IL-33 gene polymorphism (rs11792633 C/T) and risk of schizophrenia
title_sort analysis of il-33 gene polymorphism (rs11792633 c/t) and risk of schizophrenia
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019332/
https://www.ncbi.nlm.nih.gov/pubmed/27844019
work_keys_str_mv AT korditamandanidormohammad analysisofil33genepolymorphismrs11792633ctandriskofschizophrenia
AT bahramiahmadreza analysisofil33genepolymorphismrs11792633ctandriskofschizophrenia
AT sabbaghighalenoraziye analysisofil33genepolymorphismrs11792633ctandriskofschizophrenia
AT soleimanihanieh analysisofil33genepolymorphismrs11792633ctandriskofschizophrenia
AT baranzehitayebe analysisofil33genepolymorphismrs11792633ctandriskofschizophrenia

Ejemplares similares