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Odorant Responses and Courtship Behaviors Influenced by at4 Neurons in Drosophila

In insects, pheromones function as triggers to elicit complex behavior programs, such as courtship and mating behavior. In most species, the neurons tuned to pheromones are localized in a specific subset of olfactory sensilla located on the antenna called trichoid sensilla. In Drosophila there are t...

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Autores principales: Pitts, Svetlana, Pelser, Elizabeth, Meeks, Julian, Smith, Dean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019410/
https://www.ncbi.nlm.nih.gov/pubmed/27617442
http://dx.doi.org/10.1371/journal.pone.0162761
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author Pitts, Svetlana
Pelser, Elizabeth
Meeks, Julian
Smith, Dean
author_facet Pitts, Svetlana
Pelser, Elizabeth
Meeks, Julian
Smith, Dean
author_sort Pitts, Svetlana
collection PubMed
description In insects, pheromones function as triggers to elicit complex behavior programs, such as courtship and mating behavior. In most species, the neurons tuned to pheromones are localized in a specific subset of olfactory sensilla located on the antenna called trichoid sensilla. In Drosophila there are two classes of trichoid sensilla, at1 sensilla that contain the dendrites of a single neuron that is specifically tuned to the male-specific pheromone 11-cis vaccenyl acetate (cVA), and at4 sensilla that contain three neurons with relatively poorly defined chemical specificity and function. Using a combination of odorant receptor mutant analysis, single sensillum electrophysiology and optogenetics, we have examined the chemical tuning and behavioral consequences of the three at4 olfactory neuron classes. Our results indicate that one class, Or65abc neurons, are unresponsive to cVA pheromone, and function to inhibit courtship behaviors in response to an unknown ligand, while the other two neuron classes, Or88a and Or47b neurons, are sensitive to a diverse array of fly and non-fly odors, and activation of these neurons has little direct impact on courtship behaviors.
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spelling pubmed-50194102016-09-27 Odorant Responses and Courtship Behaviors Influenced by at4 Neurons in Drosophila Pitts, Svetlana Pelser, Elizabeth Meeks, Julian Smith, Dean PLoS One Research Article In insects, pheromones function as triggers to elicit complex behavior programs, such as courtship and mating behavior. In most species, the neurons tuned to pheromones are localized in a specific subset of olfactory sensilla located on the antenna called trichoid sensilla. In Drosophila there are two classes of trichoid sensilla, at1 sensilla that contain the dendrites of a single neuron that is specifically tuned to the male-specific pheromone 11-cis vaccenyl acetate (cVA), and at4 sensilla that contain three neurons with relatively poorly defined chemical specificity and function. Using a combination of odorant receptor mutant analysis, single sensillum electrophysiology and optogenetics, we have examined the chemical tuning and behavioral consequences of the three at4 olfactory neuron classes. Our results indicate that one class, Or65abc neurons, are unresponsive to cVA pheromone, and function to inhibit courtship behaviors in response to an unknown ligand, while the other two neuron classes, Or88a and Or47b neurons, are sensitive to a diverse array of fly and non-fly odors, and activation of these neurons has little direct impact on courtship behaviors. Public Library of Science 2016-09-12 /pmc/articles/PMC5019410/ /pubmed/27617442 http://dx.doi.org/10.1371/journal.pone.0162761 Text en © 2016 Pitts et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Pitts, Svetlana
Pelser, Elizabeth
Meeks, Julian
Smith, Dean
Odorant Responses and Courtship Behaviors Influenced by at4 Neurons in Drosophila
title Odorant Responses and Courtship Behaviors Influenced by at4 Neurons in Drosophila
title_full Odorant Responses and Courtship Behaviors Influenced by at4 Neurons in Drosophila
title_fullStr Odorant Responses and Courtship Behaviors Influenced by at4 Neurons in Drosophila
title_full_unstemmed Odorant Responses and Courtship Behaviors Influenced by at4 Neurons in Drosophila
title_short Odorant Responses and Courtship Behaviors Influenced by at4 Neurons in Drosophila
title_sort odorant responses and courtship behaviors influenced by at4 neurons in drosophila
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019410/
https://www.ncbi.nlm.nih.gov/pubmed/27617442
http://dx.doi.org/10.1371/journal.pone.0162761
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