Novel chlorambucil-conjugated anionic linear-globular PEG-based second-generation dendrimer: in vitro/in vivo improved anticancer activity

Evaluating the efficacy of anticancer drugs is an evolving and research-oriented issue. The objective of this study was to reduce the insolubility of chlorambucil (CBL) in water and improve the anticancer activity of CBL in vitro and in vivo through the conjugation of CBL with anionic linear-globula...

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Detalles Bibliográficos
Autores principales: Assadi, Artin, Najafabadi, Vahideh Sharifi, Shandiz, Seyed Ataollah Sadat, Boroujeni, Azadah Shayeq, Ashrafi, Sepehr, Vaziri, Ali Zaman, Ghoreishi, Seyedeh Masoumeh, Aghasadeghi, Mohammad Reza, Ebrahimi, Seyed Esmaeil Sadat, Pirali-Hamedani, Morteza, Ardestani, Mehdi Shafiee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019448/
https://www.ncbi.nlm.nih.gov/pubmed/27660471
http://dx.doi.org/10.2147/OTT.S103487

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